Artificial intelligence-assisted assessment of metabolic response to tebentafusp in metastatic uveal melanoma: a long axial field-of-view (18F)FDG PET/CT study
Tebentafusp has emerged as the first systemic therapy to significantly prolong survival in treatment-naïve HLA-A*02:01 + patients with unresectable or metastatic uveal melanoma (mUM). Notably, a survival benefit has been observed even in the absence of radiographic response. This study aims to inve...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 September 2025
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| In: |
European journal of nuclear medicine and molecular imaging
Year: 2025, Pages: 1-11 |
| ISSN: | 1619-7089 |
| DOI: | 10.1007/s00259-025-07504-8 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00259-025-07504-8 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1007/s00259-025-07504-8?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate 
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| Verfasserangaben: | Christos Sachpekidis, Devayani Machiraju, Dimitrios Stefanos Strauss, Leyun Pan, Annette Kopp-Schneider, Lars Edenbrandt, Antonia Dimitrakopoulou-Strauss, Jessica C. Hassel |
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| 246 | 1 | |i Artificial intelligence-assisted assessment of metabolic response to tebentafusp in metastatic uveal melanoma |a a long axial field-of-view (18 F) FDG PET/CT study | |
| 264 | 1 | |c 06 September 2025 | |
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| 520 | |a Tebentafusp has emerged as the first systemic therapy to significantly prolong survival in treatment-naïve HLA-A*02:01 + patients with unresectable or metastatic uveal melanoma (mUM). Notably, a survival benefit has been observed even in the absence of radiographic response. This study aims to investigate the feasibility and prognostic value of artificial intelligence (AI)-assisted quantification and metabolic response assessment of [18F]FDG long axial field-of-view (LAFOV) PET/CT in mUM patients undergoing tebentafusp therapy. | ||
| 650 | 4 | |a [18F]FDG LAFOV PET/CT | |
| 650 | 4 | |a Artificial intelligence | |
| 650 | 4 | |a CtDNA | |
| 650 | 4 | |a Deep learning | |
| 650 | 4 | |a Metastatic uveal melanoma | |
| 650 | 4 | |a PERCIST | |
| 650 | 4 | |a Tebentafusp | |
| 650 | 4 | |a Total lesion glycolysis (TLG) | |
| 650 | 4 | |a Total metabolic tumor volume (TMTV) | |
| 650 | 4 | |a Treatment response evaluation | |
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