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Prognostic scores for patients with multiple brain metastases treated with repeated stereotactic radiosurgery - a secondary analysis of the CYBER-SPACE randomized phase 2 trial

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Background - Stereotactic radiosurgery (SRS) is frequently combined with modern systemic therapy for brain metastases (BM). Most established prognostic scores were developed from historical cohorts and may not reflect current treatment standards. The randomized phase II CYBER-SPACE trial investigate...

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Main Authors: Schiele, Annabella (Author) , Bernhardt, Denise (Author) , Welzel, Thomas (Author) , Thalmann, Paul (Author) , König, Laila (Author) , Eichkorn, Tanja (Author) , Krämer, Anna (Author) , Uzun-Lang, Kristin (Author) , Hommertgen, Adriane (Author) , Weykamp, Fabian (Author) , Bozorgmehr, Farastuk (Author) , Thomas, Michael (Author) , Sander, Anja (Author) , Rieken, Stefan (Author) , Debus, Jürgen (Author) , El-Shafie, Rami (Author)
Format: Article (Journal)
Language:English
Published: January 2026
In: Radiotherapy and oncology
Year: 2026, Volume: 214, Pages: 1-10
ISSN:1879-0887
DOI:10.1016/j.radonc.2025.111279
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radonc.2025.111279
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0167814025052831
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Author Notes:Annabella Schiele, Denise Bernhardt, Thomas Welzel, Paul Thalmann, Laila König, Tanja Eichkorn, Anna Krämer, Kristin Lang, Adriane Lentz-Hommertgen, Fabian Weykamp, Farastuk Bozorgmehr, Michael Thomas, Anja Sander, Stefan Rieken, Jürgen Debus, Rami A. El Shafie
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