Analysis of soluble interleukin-2 receptor as a prognostic biomarker in NMOSD and MOGAD
Objective Soluble interleukin-2 receptor (sIL-2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) pathogenesis. However, sIL-2R has so far not been evaluated in the...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 2025
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| In: |
Annals of Clinical and Translational Neurology
Year: 2025, Jahrgang: 12, Heft: 12, Pages: 2460-2469 |
| ISSN: | 2328-9503 |
| DOI: | 10.1002/acn3.70186 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/acn3.70186 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/acn3.70186 
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| Verfasserangaben: | Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann-Strobl, Friedemann Paul, Patrick Schindler |
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| 245 | 1 | 0 | |a Analysis of soluble interleukin-2 receptor as a prognostic biomarker in NMOSD and MOGAD |c Philipp Klyscz, Carolin Otto, Klemens Ruprecht, Susanna Asseyer, Hannes Ole Tiedt, Christian Meisel, Judith Bellmann-Strobl, Friedemann Paul, Patrick Schindler |
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| 520 | |a Objective Soluble interleukin-2 receptor (sIL-2R) is a biomarker for T cell activity. T cells are involved in neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) pathogenesis. However, sIL-2R has so far not been evaluated in these conditions. Here, we compared sIL-2R levels in serum and cerebrospinal fluid (CSF) of patients with aquaporin-4-IgG-seropositive and seronegative (AQP4-IgG+/−) NMOSD, MOGAD, and noninflammatory neurologic disorders (NINDs), and assessed the prognostic value of sIL-2R for future attacks. Methods Retrospective analysis of real-world data of patients treated at Charité—Universitätsmedizin Berlin was conducted (45 MOGAD, 14 AQP4-IgG+NMOSD, 10 AQP4-IgG−NMOSD, 69 NINDs) between 2010 and 2024. Mean (SD) follow-up time was 40 (35) months. sIL-2R differences were assessed by linear mixed models. Cox regression analysis was performed to investigate the predictive value for subsequent attacks. Results Serum sIL-2R was higher in AQP4-IgG+NMOSD (estimated marginal mean [EMM] 802 IU/mL) and MOGAD (569 IU/mL) compared to NINDs (404 IU/mL). In patients with a first manifestation of MOGAD, but not NMOSD, serum sIL-2R (HR = 9.07 [95% CI 1.37-60.01]) and CSF sIL-2R (HR = 3.27 [95% CI 0.61-17.45]) levels were predictive for subsequent attacks. Interpretation Serum sIL-2R is elevated in AQP4-IgG+NMOSD and MOGAD and may be a prognostic biomarker for a relapsing disease course in MOGAD. | ||
| 650 | 4 | |a biomarker | |
| 650 | 4 | |a MOGAD | |
| 650 | 4 | |a NMOSD | |
| 650 | 4 | |a soluble interleukin-2 receptor | |
| 700 | 1 | |a Otto, Carolin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruprecht, Klemens |d 1971- |e VerfasserIn |0 (DE-588)121955699 |0 (DE-627)081645511 |0 (DE-576)293016720 |4 aut | |
| 700 | 1 | |a Asseyer, Susanna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tiedt, Hannes Ole |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meisel, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bellmann-Strobl, Judith |e VerfasserIn |4 aut | |
| 700 | 1 | |a Paul, Friedemann |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schindler, Patrick |e VerfasserIn |0 (DE-588)1279625066 |0 (DE-627)183275622X |4 aut | |
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