Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma

The therapeutic landscape of advanced urothelial carcinoma (UC) is evolving, making the prediction of immune checkpoint inhibitor (ICI) therapy efficacy crucial. Standalone biomarkers offer limited predictive value, necessitating integrative approaches combining clinicopathological, laboratory, and...

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Main Authors:	Váradi, Melinda (Author) , Horváth, O. (Author) , Soós, E. (Author) , Csizmarik, A. (Author) , Németh, B. (Author) , Győrffy, B. (Author) , Kenessey, I. (Author) , Reis, H. (Author) , Koll, F. (Author) , Oláh, C. (Author) , Hadaschik, B. (Author) , Krafft, U. (Author) , Grünwald, V. (Author) , Mairinger, F. (Author) , Wessolly, M. (Author) , Hoffmann, M. J. (Author) , Grunewald, C. M. (Author) , Niegisch, G. (Author) , López-Cotarelo Rodríguez-Noriega, Cristina (Author) , Maráz, A. (Author) , Kuthi, L. (Author) , Szász, A. M. (Author) , Herold, Z. (Author) , Posta, M. (Author) , Bátai, B. (Author) , Nyirády, P. (Author) , Szarvas, T. (Author)
Format:	Article (Journal)
Language:	English
Published:	December 2025
In:	Cancer immunology immunotherapy Year: 2025, Volume: 74, Issue: 12, Pages: 1-16
ISSN:	1432-0851
DOI:	10.1007/s00262-025-04224-8
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-025-04224-8
Author Notes:	M. Váradi, O. Horváth, E. Soós, A. Csizmarik, B. Németh, B. Győrffy, I. Kenessey, H. Reis, F. Koll, C. Oláh, B. Hadaschik, U. Krafft, V. Grünwald, F. Mairinger, M. Wessolly, M.J. Hoffmann, C.M. Grunewald, G. Niegisch, C.L. Cotarelo, A. Maráz, L. Kuthi, A.M. Szász, Z. Herold, M. Posta, B. Bátai, P. Nyirády, T. Szarvas