Buchumschlag

Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma

The therapeutic landscape of advanced urothelial carcinoma (UC) is evolving, making the prediction of immune checkpoint inhibitor (ICI) therapy efficacy crucial. Standalone biomarkers offer limited predictive value, necessitating integrative approaches combining clinicopathological, laboratory, and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Váradi, Melinda (VerfasserIn) , Horváth, O. (VerfasserIn) , Soós, E. (VerfasserIn) , Csizmarik, A. (VerfasserIn) , Németh, B. (VerfasserIn) , Győrffy, B. (VerfasserIn) , Kenessey, I. (VerfasserIn) , Reis, H. (VerfasserIn) , Koll, F. (VerfasserIn) , Oláh, C. (VerfasserIn) , Hadaschik, B. (VerfasserIn) , Krafft, U. (VerfasserIn) , Grünwald, V. (VerfasserIn) , Mairinger, F. (VerfasserIn) , Wessolly, M. (VerfasserIn) , Hoffmann, M. J. (VerfasserIn) , Grunewald, C. M. (VerfasserIn) , Niegisch, G. (VerfasserIn) , López-Cotarelo Rodríguez-Noriega, Cristina (VerfasserIn) , Maráz, A. (VerfasserIn) , Kuthi, L. (VerfasserIn) , Szász, A. M. (VerfasserIn) , Herold, Z. (VerfasserIn) , Posta, M. (VerfasserIn) , Bátai, B. (VerfasserIn) , Nyirády, P. (VerfasserIn) , Szarvas, T. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: December 2025
In: Cancer immunology immunotherapy
Year: 2025, Jahrgang: 74, Heft: 12, Pages: 1-16
ISSN:1432-0851
DOI:10.1007/s00262-025-04224-8
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00262-025-04224-8
Volltext
Verfasserangaben:M. Váradi, O. Horváth, E. Soós, A. Csizmarik, B. Németh, B. Győrffy, I. Kenessey, H. Reis, F. Koll, C. Oláh, B. Hadaschik, U. Krafft, V. Grünwald, F. Mairinger, M. Wessolly, M.J. Hoffmann, C.M. Grunewald, G. Niegisch, C.L. Cotarelo, A. Maráz, L. Kuthi, A.M. Szász, Z. Herold, M. Posta, B. Bátai, P. Nyirády, T. Szarvas

MARC

LEADER 00000naa a2200000 c 4500
001 195056519X
003 DE-627
005 20260129093901.0
007 cr uuu---uuuuu
008 260129s2025 xx |||||o 00| ||eng c
024 7 |a 10.1007/s00262-025-04224-8  |2 doi 
035 |a (DE-627)195056519X 
035 |a (DE-599)KXP195056519X 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Váradi, Melinda  |e VerfasserIn  |0 (DE-588)1388303256  |0 (DE-627)1950565742  |4 aut 
245 1 0 |a Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma  |c M. Váradi, O. Horváth, E. Soós, A. Csizmarik, B. Németh, B. Győrffy, I. Kenessey, H. Reis, F. Koll, C. Oláh, B. Hadaschik, U. Krafft, V. Grünwald, F. Mairinger, M. Wessolly, M.J. Hoffmann, C.M. Grunewald, G. Niegisch, C.L. Cotarelo, A. Maráz, L. Kuthi, A.M. Szász, Z. Herold, M. Posta, B. Bátai, P. Nyirády, T. Szarvas 
264 1 |c December 2025 
300 |b Diagramme 
300 |a 16 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 12. November 2025 
500 |a Gesehen am 29.01.2026 
520 |a The therapeutic landscape of advanced urothelial carcinoma (UC) is evolving, making the prediction of immune checkpoint inhibitor (ICI) therapy efficacy crucial. Standalone biomarkers offer limited predictive value, necessitating integrative approaches combining clinicopathological, laboratory, and molecular factors to enhance accuracy. This study aimed to evaluate clinical and molecular factors, including the real-life performance of PD-L1 IHC, to improve treatment outcome prediction in ICI-treated UC patients, ultimately developing a more precise therapy selection model. 
650 4 |a Gene expression based markers 
650 4 |a Immune checkpoint inhibitors 
650 4 |a Molecular subtypes 
650 4 |a PD-L1 
650 4 |a Urothelial carcinoma 
700 1 |a Horváth, O.  |e VerfasserIn  |4 aut 
700 1 |a Soós, E.  |e VerfasserIn  |4 aut 
700 1 |a Csizmarik, A.  |e VerfasserIn  |4 aut 
700 1 |a Németh, B.  |e VerfasserIn  |4 aut 
700 1 |a Győrffy, B.  |e VerfasserIn  |4 aut 
700 1 |a Kenessey, I.  |e VerfasserIn  |4 aut 
700 1 |a Reis, H.  |e VerfasserIn  |4 aut 
700 1 |a Koll, F.  |e VerfasserIn  |4 aut 
700 1 |a Oláh, C.  |e VerfasserIn  |4 aut 
700 1 |a Hadaschik, B.  |e VerfasserIn  |4 aut 
700 1 |a Krafft, U.  |e VerfasserIn  |4 aut 
700 1 |a Grünwald, V.  |e VerfasserIn  |4 aut 
700 1 |a Mairinger, F.  |e VerfasserIn  |4 aut 
700 1 |a Wessolly, M.  |e VerfasserIn  |4 aut 
700 1 |a Hoffmann, M. J.  |e VerfasserIn  |4 aut 
700 1 |a Grunewald, C. M.  |e VerfasserIn  |4 aut 
700 1 |a Niegisch, G.  |e VerfasserIn  |4 aut 
700 1 |a López-Cotarelo Rodríguez-Noriega, Cristina  |d 1970-  |e VerfasserIn  |0 (DE-588)121996662  |0 (DE-627)705730646  |0 (DE-576)29303799X  |4 aut 
700 1 |a Maráz, A.  |e VerfasserIn  |4 aut 
700 1 |a Kuthi, L.  |e VerfasserIn  |4 aut 
700 1 |a Szász, A. M.  |e VerfasserIn  |4 aut 
700 1 |a Herold, Z.  |e VerfasserIn  |4 aut 
700 1 |a Posta, M.  |e VerfasserIn  |4 aut 
700 1 |a Bátai, B.  |e VerfasserIn  |4 aut 
700 1 |a Nyirády, P.  |e VerfasserIn  |4 aut 
700 1 |a Szarvas, T.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Cancer immunology immunotherapy  |d Berlin : Springer, 1976  |g 74(2025), 12 vom: Dez., Artikel-ID 370, Seite 1-16  |h Online-Ressource  |w (DE-627)253390443  |w (DE-600)1458489-X  |w (DE-576)072283475  |x 1432-0851  |7 nnas  |a Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma 
773 1 8 |g volume:74  |g year:2025  |g number:12  |g month:12  |g elocationid:370  |g pages:1-16  |g extent:16  |a Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma 
856 4 0 |u https://doi.org/10.1007/s00262-025-04224-8  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext  |7 0 
951 |a AR 
992 |a 20260129 
993 |a Article 
994 |a 2025 
998 |g 121996662  |a López-Cotarelo Rodríguez-Noriega, Cristina  |m 121996662:López-Cotarelo Rodríguez-Noriega, Cristina  |d 60000  |d 63400  |e 60000PL121996662  |e 63400PL121996662  |k 0/60000/  |k 1/60000/63400/  |p 19 
999 |a KXP-PPN195056519X  |e 4864195722 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title":"Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma","title_sort":"Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinoma"}],"person":[{"role":"aut","given":"Melinda","display":"Váradi, Melinda","family":"Váradi"},{"display":"Horváth, O.","role":"aut","given":"O.","family":"Horváth"},{"display":"Soós, E.","role":"aut","given":"E.","family":"Soós"},{"given":"A.","role":"aut","display":"Csizmarik, A.","family":"Csizmarik"},{"family":"Németh","display":"Németh, B.","given":"B.","role":"aut"},{"display":"Győrffy, B.","role":"aut","given":"B.","family":"Győrffy"},{"display":"Kenessey, I.","role":"aut","given":"I.","family":"Kenessey"},{"display":"Reis, H.","role":"aut","given":"H.","family":"Reis"},{"display":"Koll, F.","role":"aut","given":"F.","family":"Koll"},{"display":"Oláh, C.","given":"C.","role":"aut","family":"Oláh"},{"family":"Hadaschik","display":"Hadaschik, B.","role":"aut","given":"B."},{"family":"Krafft","display":"Krafft, U.","role":"aut","given":"U."},{"family":"Grünwald","given":"V.","role":"aut","display":"Grünwald, V."},{"family":"Mairinger","given":"F.","role":"aut","display":"Mairinger, F."},{"given":"M.","role":"aut","display":"Wessolly, M.","family":"Wessolly"},{"family":"Hoffmann","role":"aut","given":"M. J.","display":"Hoffmann, M. J."},{"given":"C. M.","role":"aut","display":"Grunewald, C. M.","family":"Grunewald"},{"display":"Niegisch, G.","given":"G.","role":"aut","family":"Niegisch"},{"given":"Cristina","role":"aut","display":"López-Cotarelo Rodríguez-Noriega, Cristina","family":"López-Cotarelo Rodríguez-Noriega"},{"family":"Maráz","role":"aut","given":"A.","display":"Maráz, A."},{"family":"Kuthi","role":"aut","given":"L.","display":"Kuthi, L."},{"family":"Szász","given":"A. M.","role":"aut","display":"Szász, A. M."},{"family":"Herold","given":"Z.","role":"aut","display":"Herold, Z."},{"display":"Posta, M.","role":"aut","given":"M.","family":"Posta"},{"family":"Bátai","display":"Bátai, B.","role":"aut","given":"B."},{"display":"Nyirády, P.","role":"aut","given":"P.","family":"Nyirády"},{"given":"T.","role":"aut","display":"Szarvas, T.","family":"Szarvas"}],"name":{"displayForm":["M. Váradi, O. Horváth, E. Soós, A. Csizmarik, B. Németh, B. Győrffy, I. Kenessey, H. Reis, F. Koll, C. Oláh, B. Hadaschik, U. Krafft, V. Grünwald, F. Mairinger, M. Wessolly, M.J. Hoffmann, C.M. Grunewald, G. Niegisch, C.L. Cotarelo, A. Maráz, L. Kuthi, A.M. Szász, Z. Herold, M. Posta, B. Bátai, P. Nyirády, T. Szarvas"]},"relHost":[{"origin":[{"publisher":"Springer","dateIssuedDisp":"1976-","dateIssuedKey":"1976","publisherPlace":"Berlin ; Heidelberg"}],"recId":"253390443","type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"CII"}],"disp":"Combining molecular patterns and clinical data for better immune checkpoint inhibitor prediction in metastatic urothelial carcinomaCancer immunology immunotherapy","id":{"zdb":["1458489-X"],"issn":["1432-0851"],"eki":["253390443"]},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 15.05.2024","Fortsetzung der Druck-Ausgabe","Ungezählte Beil. ab 52.2003: Supplement"],"pubHistory":["1.1976 -"],"title":[{"title_sort":"Cancer immunology immunotherapy","subtitle":"CII","title":"Cancer immunology immunotherapy"}],"part":{"extent":"16","pages":"1-16","issue":"12","text":"74(2025), 12 vom: Dez., Artikel-ID 370, Seite 1-16","year":"2025","volume":"74"},"language":["eng"]}],"note":["Online veröffentlicht: 12. November 2025","Gesehen am 29.01.2026"],"physDesc":[{"noteIll":"Diagramme","extent":"16 S."}],"id":{"doi":["10.1007/s00262-025-04224-8"],"eki":["195056519X"]},"origin":[{"dateIssuedDisp":"December 2025","dateIssuedKey":"2025"}],"recId":"195056519X","type":{"media":"Online-Ressource","bibl":"article-journal"}} 
SRT |a VARADIMELICOMBININGM2025 

Ähnliche Einträge