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Effects of personalized live-remote exercise for individuals living beyond primary curative cancer treatment: study protocol for a multinational, super umbrella randomized controlled trial (LION-RCT)

Exercise is an effective strategy to reduce cancer- and treatment-related side effects and improve quality of life (QoL). Larger exercise effects are observed in cancer survivors with a higher symptom burden and when exercise interventions are supervised. Most studies conducted to date have not scre...

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Main Authors: Hiensch, Anouk (Author) , Müller, Jana (Author) , Zopf, Eva M. (Author) , Schmidt, Martina (Author) , Monninkhof, Evelyn M. (Author) , Trevaskis, Mark (Author) , Belloso, Jon (Author) , Clauss, Dorothea (Author) , Gunasekara, Nadira (Author) , Joaquim, Ana (Author) , Viamonte, Sofia (Author) , Schumann, Moritz (Author) , Heinrich, Lars (Author) , Kias, Alina (Author) , Binyam, David (Author) , van de Poll, Lonneke (Author) , Buffart, Laurien M. (Author) , Aaronson, Neil K. (Author) , van der Wall, Elsken (Author) , Campbell, Anna (Author) , Wiskemann, Joachim (Author) , Rundqvist, Helene (Author) , Alves, Alberto J. (Author) , Urruticoechea, Ander (Author) , Bloch, Wilhelm (Author) , Stuiver, Martijn M. (Author) , Wengström, Yvonne (Author) , Steindorf, Karen (Author) , May, Anne M. (Author)
Format: Article (Journal)
Language:English
Published: 24 November 2025
In: Trials
Year: 2025, Volume: 26, Pages: 1-16
ISSN:1468-6694
DOI:10.1186/s13063-025-09263-1
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13063-025-09263-1
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Author Notes:Anouk E. Hiensch, Jana Müller, Eva M. Zopf, Martina E. Schmidt, Evelyn M. Monninkhof, Mark Trevaskis, Jon Belloso, Dorothea Clauss, Nadira Gunasekara, Ana Joaquim, Sofia Viamonte, Moritz Schumann, Lars Heinrich, Alina Kias, David Binyam, Lonneke van de Poll, Laurien M. Buffart, Neil K. Aaronson, Elsken van der Wall, Anna Campbell, Joachim Wiskemann, Helene Rundqvist, Alberto J. Alves, Ander Urruticoechea, Wilhelm Bloch, Martijn M. Stuiver, Yvonne Wengström, Karen Steindorf and Anne M. May
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Summary:Exercise is an effective strategy to reduce cancer- and treatment-related side effects and improve quality of life (QoL). Larger exercise effects are observed in cancer survivors with a higher symptom burden and when exercise interventions are supervised. Most studies conducted to date have not screened for symptoms at baseline and tailored the exercise intervention accordingly. Additionally, time and travel distance are common barriers to participation in supervised in-person exercise programs. Live-remote exercise, where exercise sessions are supervised by an exercise professional via a videoconferencing platform, might help overcome these barriers. Here, we describe the design of the LION randomized controlled trial (RCT). This RCT aims to assess the (cost-)effectiveness of side effect-targeted, live-remote exercise on QoL and the participants’ most burdensome side effect—fatigue, emotional distress, low physical functioning, or chemotherapy-induced peripheral neuropathy (CIPN)—in individuals who have completed primary curative cancer treatment.
Item Description:Veröffentlicht: 24. November 2025
Gesehen am 29.01.2026
Physical Description:Online Resource
ISSN:1468-6694
DOI:10.1186/s13063-025-09263-1

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