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Ten-year follow-up after 96 weeks treatment with Peginterferon plus tenofovir in Hepatitis D (HIDIT-II): improved clinical outcome after combination therapy

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Background Chronic delta hepatitis represents a major health burden. Until recently, pegylated interferon-alfa-2a (PEG-IFNα) therapy was the only treatment option for patients infected with hepatitis D virus (HDV). The aim of this study was to evaluate 10-year long-term clinical and virological outc...

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Main Authors: Yurdaydin, Cihan (Author) , Kahlhöfer, Julia (Author) , Caruntu, Florin Alexandru (Author) , Yalcin, Kendal (Author) , Gürel, Selim (Author) , Akarca, Ulus S. (Author) , Sprinzl, Kathrin (Author) , Bock, Hans H. (Author) , Bockmann, Jan-Hendrik (Author) , Papatheodoridis, George V. (Author) , Merle, Uta (Author) , Demir, Münevver (Author) , Hardtke, Svenja (Author) , Keskin, Onur (Author) , Idilman, Ramazan (Author) , Cornberg, Markus (Author) , Wedemeyer, Heiner (Author) , Wranke, Anika (Author)
Format: Article (Journal)
Language:English
Published: February 2026
In: United european gastroenterology journal
Year: 2026, Volume: 14, Issue: 1, Pages: 1-10
ISSN:2050-6414
DOI:10.1002/ueg2.70153
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/ueg2.70153
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ueg2.70153
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Author Notes:Cihan Yurdaydin, Julia Kahlhöfer, Florin Alexandru Caruntu, Kendal Yalcin, Selim Gürel, Ulus S. Akarca, Kathrin Sprinzl, Hans H. Bock, Jan-Hendrik Bockmann, George V. Papatheodoridis, Uta Merle, Münevver Demir, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Markus Cornberg, Heiner Wedemeyer, Anika Wranke
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Real-world effectiveness and safety of bulevirtide monotherapy for up to 96 weeks in patients with HDV-related cirrhosis by Degasperi, Elisabetta (Author) , Anolli, Maria Paola (Author) , Jachs, Mathias (Author) , Reiberger, Thomas (Author) , De Ledinghen, Victor (Author) , Metivier, Sophie (Author) , D’Offizi, Gianpiero (Author) , di Maria, Francesco (Author) , Schramm, Christoph (Author) , Schmidt, Hartmut (Author) , Zöllner, Caroline (Author) , Tacke, Frank (Author) , Dietz-Fricke, Christopher (Author) , Wedemeyer, Heiner (Author) , Papatheodoridi, Margarita (Author) , Papatheodoridis, George (Author) , Carey, Ivana (Author) , Agarwal, Kosh (Author) , Van Bömmel, Florian (Author) , Brunetto, Maurizia R. (Author) , Cardoso, Mariana (Author) , Verucchi, Gabriella (Author) , Ciancio, Alessia (Author) , Zoulim, Fabien (Author) , Aleman, Soo (Author) , Semmo, Nasser (Author) , Mangia, Alessandra (Author) , Hilleret, Marie-Noelle (Author) , Merle, Uta (Author) , Santantonio, Teresa A. (Author) , Coppola, Nicola (Author) , Pellicelli, Adriano (Author) , Roche, Bruno (Author) , Causse, Xavier (Author) , D’Alteroche, Louis (Author) , Dumortier, Jérome (Author) , Ganne, Nathalie (Author) , Heluwaert, Frederic (Author) , Ollivier, Isabelle (Author) , Roulot, Dominique (Author) , Viganò, Mauro (Author) , Loglio, Alessandro (Author) , Federico, Alessandro (Author) , Pileri, Francesca (Author) , Maracci, Monia (Author) , Tonnini, Matteo (Author) , Arpurt, Jean-Pierre (Author) , Barange, Karl (Author) , Billaud, Eric (Author) , Pol, Stanislas (Author) , Gervais, Anne (Author) , Minello, Anne (Author) , Rosa, Isabelle (Author) , Puoti, Massimo (Author) , Lampertico, Pietro (Author) ,


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