Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease
Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson’s disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in mice, we hypothesized that STN-DBS can mimic dopa...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
September 12, 2025
|
| In: |
Science advances
Year: 2025, Volume: 11, Issue: 37, Pages: 1-14 |
| ISSN: | 2375-2548 |
| DOI: | 10.1126/sciadv.adx6849 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adx6849 Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.adx6849 
|
| Author Notes: | Alessia Cavallo, Richard M. Köhler, Johannes L. Busch, Jeroen G.V. Habets, Timon Merk, Patricia Zvarova, Jojo Vanhoecke, Thomas S. Binns, Bassam Al-Fatly, Ana Luisa de Almeida Marcelino, Natasha Darcy, Gerd-Helge Schneider, Patricia Krause, Andreas Horn, Katharina Faust, Damian M. Herz, Eric Yttri, Hayriye Cagnan, Andrea A. Kühn, Wolf-Julian Neumann |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1950966194 | ||
| 003 | DE-627 | ||
| 005 | 20260203103056.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260203s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1126/sciadv.adx6849 |2 doi | |
| 035 | |a (DE-627)1950966194 | ||
| 035 | |a (DE-599)KXP1950966194 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Cavallo, Alessia |e VerfasserIn |0 (DE-588)1388846926 |0 (DE-627)1950967441 |4 aut | |
| 245 | 1 | 0 | |a Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease |c Alessia Cavallo, Richard M. Köhler, Johannes L. Busch, Jeroen G.V. Habets, Timon Merk, Patricia Zvarova, Jojo Vanhoecke, Thomas S. Binns, Bassam Al-Fatly, Ana Luisa de Almeida Marcelino, Natasha Darcy, Gerd-Helge Schneider, Patricia Krause, Andreas Horn, Katharina Faust, Damian M. Herz, Eric Yttri, Hayriye Cagnan, Andrea A. Kühn, Wolf-Julian Neumann |
| 264 | 1 | |c September 12, 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.02.2026 | ||
| 520 | |a Subthalamic deep brain stimulation (STN-DBS) provides unprecedented spatiotemporal precision for the treatment of Parkinson’s disease (PD), allowing for direct real-time state-specific adjustments. Inspired by findings from optogenetic stimulation in mice, we hypothesized that STN-DBS can mimic dopaminergic reinforcement of ongoing movement kinematics during stimulation. To investigate this hypothesis, we delivered DBS bursts during particularly fast and slow movements in 24 patients with PD. Our findings reveal that DBS during fast movements enhanced future movement speed more than DBS during slow movements, raising movement speed to the level of healthy controls. To understand which brain circuits mediate this neurophysiological mechanism, we investigated the behavioral effects using magnetic resonance imaging connectomics and motor cortex electrocorticography. Last, we demonstrate that machine learning-based brain signal decoding can be used to predict continuous movement speed for fully embedded state-dependent closed-loop algorithms. Our findings provide important evidence for reinforcement-based DBS circuit mechanisms that may inspire previously unexplored treatment avenues for dopaminergic disorders. | ||
| 700 | 1 | |a Köhler, Richard M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Busch, Johannes L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Habets, Jeroen G. V. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Merk, Timon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zvarova, Patricia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vanhoecke, Jojo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Binns, Thomas S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Al-Fatly, Bassam |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Almeida Marcelino, Ana Luisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Darcy, Natasha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schneider, Gerd-Helge |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krause, Patricia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Horn, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Faust, Katharina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herz, Damian |d 1982- |e VerfasserIn |0 (DE-588)1012342433 |0 (DE-627)661396150 |0 (DE-576)34530747X |4 aut | |
| 700 | 1 | |a Yttri, Eric |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cagnan, Hayriye |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kühn, Andrea A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neumann, Wolf-Julian |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Science advances |d Washington, DC [u.a.] : Assoc., 2015 |g 11(2025), 37 vom: Sept., Artikel-ID eadx6849, Seite 1-14 |h Online-Ressource |w (DE-627)818494344 |w (DE-600)2810933-8 |w (DE-576)426498542 |x 2375-2548 |7 nnas |a Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease |
| 773 | 1 | 8 | |g volume:11 |g year:2025 |g number:37 |g month:09 |g elocationid:eadx6849 |g pages:1-14 |g extent:14 |a Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease |
| 856 | 4 | 0 | |u https://doi.org/10.1126/sciadv.adx6849 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.science.org/doi/10.1126/sciadv.adx6849 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260203 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1012342433 |a Herz, Damian |m 1012342433:Herz, Damian |d 910000 |d 911100 |e 910000PH1012342433 |e 911100PH1012342433 |k 0/910000/ |k 1/910000/911100/ |p 16 | ||
| 999 | |a KXP-PPN1950966194 |e 4874473822 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"September 12, 2025"}],"name":{"displayForm":["Alessia Cavallo, Richard M. Köhler, Johannes L. Busch, Jeroen G.V. Habets, Timon Merk, Patricia Zvarova, Jojo Vanhoecke, Thomas S. Binns, Bassam Al-Fatly, Ana Luisa de Almeida Marcelino, Natasha Darcy, Gerd-Helge Schneider, Patricia Krause, Andreas Horn, Katharina Faust, Damian M. Herz, Eric Yttri, Hayriye Cagnan, Andrea A. Kühn, Wolf-Julian Neumann"]},"recId":"1950966194","id":{"eki":["1950966194"],"doi":["10.1126/sciadv.adx6849"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"given":"Alessia","display":"Cavallo, Alessia","role":"aut","family":"Cavallo"},{"given":"Richard M.","display":"Köhler, Richard M.","role":"aut","family":"Köhler"},{"display":"Busch, Johannes L.","role":"aut","family":"Busch","given":"Johannes L."},{"given":"Jeroen G. V.","display":"Habets, Jeroen G. V.","family":"Habets","role":"aut"},{"display":"Merk, Timon","role":"aut","family":"Merk","given":"Timon"},{"role":"aut","family":"Zvarova","display":"Zvarova, Patricia","given":"Patricia"},{"display":"Vanhoecke, Jojo","family":"Vanhoecke","role":"aut","given":"Jojo"},{"family":"Binns","role":"aut","display":"Binns, Thomas S.","given":"Thomas S."},{"display":"Al-Fatly, Bassam","role":"aut","family":"Al-Fatly","given":"Bassam"},{"given":"Ana Luisa","display":"de Almeida Marcelino, Ana Luisa","family":"de Almeida Marcelino","role":"aut"},{"given":"Natasha","family":"Darcy","role":"aut","display":"Darcy, Natasha"},{"display":"Schneider, Gerd-Helge","role":"aut","family":"Schneider","given":"Gerd-Helge"},{"family":"Krause","role":"aut","display":"Krause, Patricia","given":"Patricia"},{"role":"aut","family":"Horn","display":"Horn, Andreas","given":"Andreas"},{"given":"Katharina","role":"aut","family":"Faust","display":"Faust, Katharina"},{"given":"Damian","role":"aut","family":"Herz","display":"Herz, Damian"},{"role":"aut","family":"Yttri","display":"Yttri, Eric","given":"Eric"},{"given":"Hayriye","family":"Cagnan","role":"aut","display":"Cagnan, Hayriye"},{"given":"Andrea A.","display":"Kühn, Andrea A.","family":"Kühn","role":"aut"},{"given":"Wolf-Julian","role":"aut","family":"Neumann","display":"Neumann, Wolf-Julian"}],"note":["Gesehen am 03.02.2026"],"language":["eng"],"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"14 S."}],"title":[{"title_sort":"Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease","title":"Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s disease"}],"relHost":[{"language":["eng"],"recId":"818494344","type":{"media":"Online-Ressource","bibl":"periodical"},"name":{"displayForm":["American Association for the Advancement of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"part":{"extent":"14","issue":"37","pages":"1-14","year":"2025","volume":"11","text":"11(2025), 37 vom: Sept., Artikel-ID eadx6849, Seite 1-14"},"note":["Gesehen am 13.09.21"],"pubHistory":["1.2015 -"],"id":{"eki":["818494344"],"zdb":["2810933-8"],"issn":["2375-2548"]},"disp":"Differential modulation of movement speed with state-dependent deep brain stimulation in Parkinson’s diseaseScience advances","origin":[{"dateIssuedDisp":"2015-","publisherPlace":"Washington, DC [u.a.]","dateIssuedKey":"2015","publisher":"Assoc."}],"corporate":[{"role":"isb","display":"American Association for the Advancement of Science"}],"title":[{"title_sort":"Science advances","title":"Science advances"}]}]} | ||
| SRT | |a CAVALLOALEDIFFERENTI1220 | ||