The complement: dendritic cell-endothelial cell crosstalk in vascular inflammation
Inflammation is a highly co-ordinated process involving multiple immune components, including the complement system, dendritic cells (DCs), and endothelial cells (ECs). All of them play pivotal roles in immunity and host defence and have a significant impact on cardiovascular health and disease. Whi...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 December 2025
|
| In: |
Cardiovascular research
Year: 2025, Pages: 1-16 |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvaf270 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/cvr/cvaf270
|
| Author Notes: | Serena Gregori, Manuela Sauter, Reinhard Sauter, Sofia Iris Bibli, Konstantinos Stellos, Daniel Duerschmied, Rüdiger E. Scharf, and Harald F. Langer |
MARC
| LEADER | 00000naa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1951210808 | ||
| 003 | DE-627 | ||
| 005 | 20260205122054.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260205s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cvr/cvaf270 |2 doi | |
| 035 | |a (DE-627)1951210808 | ||
| 035 | |a (DE-599)KXP1951210808 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gregori, Serena |d 1998- |e VerfasserIn |0 (DE-588)1389061078 |0 (DE-627)1951213912 |4 aut | |
| 245 | 1 | 4 | |a The complement: dendritic cell-endothelial cell crosstalk in vascular inflammation |c Serena Gregori, Manuela Sauter, Reinhard Sauter, Sofia Iris Bibli, Konstantinos Stellos, Daniel Duerschmied, Rüdiger E. Scharf, and Harald F. Langer |
| 264 | 1 | |c 18 December 2025 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.02.2026 | ||
| 520 | |a Inflammation is a highly co-ordinated process involving multiple immune components, including the complement system, dendritic cells (DCs), and endothelial cells (ECs). All of them play pivotal roles in immunity and host defence and have a significant impact on cardiovascular health and disease. While individual functions of the complement system, DCs and ECs are well-characterized, their multifaceted interplay in modulating inflammation and disease is insufficiently elucidated. The complement system exerts predominantly pro-inflammatory effects, influencing the immune, cardiovascular, and nervous systems. DCs bridge innate and adaptive immunity, shaping T-cell and B-cell responses depending on their maturation state. At the interface between tissues and circulation, ECs regulate immune cell trafficking and vascular homeostasis, while endothelial dysfunction or injury contributes to cardiovascular disorders such as atherosclerosis, hypertension, heart failure, or acute thrombotic events. We have to understand the dynamic crosstalk between the complement system, DCs and ECs, which are important for cardiovascular systems biology, to be able to identify new research avenues and potential therapeutic strategies. This article reviews current insights into these molecular networks, discussing their impact on inflammation and cardiovascular pathology. By elucidating these mechanisms, innovative approaches to prevent and manage cardiovascular diseases may emerge. | ||
| 700 | 1 | |a Sauter, Manuela |e VerfasserIn |0 (DE-588)1251518338 |0 (DE-627)1789228433 |4 aut | |
| 700 | 1 | |a Sauter, Reinhard Jörg |d 1983- |e VerfasserIn |0 (DE-588)1064672426 |0 (DE-627)814177336 |0 (DE-576)424022729 |4 aut | |
| 700 | 1 | |a Bibli, Sofia-Iris |e VerfasserIn |0 (DE-588)1341529843 |0 (DE-627)1902258363 |4 aut | |
| 700 | 1 | |a Stellos, Konstantinos |d 1981- |e VerfasserIn |0 (DE-588)133214354 |0 (DE-627)538682132 |0 (DE-576)272835803 |4 aut | |
| 700 | 1 | |a Dürschmied, Daniel |d 1976- |e VerfasserIn |0 (DE-588)129152196 |0 (DE-627)390022462 |0 (DE-576)187844623 |4 aut | |
| 700 | 1 | |a Scharf, Rüdiger Eberhard |e VerfasserIn |0 (DE-588)121368790X |0 (DE-627)1724517325 |4 aut | |
| 700 | 1 | |a Langer, Harald |d 1976- |e VerfasserIn |0 (DE-588)129436038 |0 (DE-627)707238072 |0 (DE-576)297659286 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cardiovascular research |d Oxford : Oxford University Press, 1967 |g (2025), Artikel-ID cvaf270, Seite 1-16 |h Online-Ressource |w (DE-627)306654393 |w (DE-600)1499917-1 |w (DE-576)081984685 |x 1755-3245 |7 nnas |a The complement: dendritic cell-endothelial cell crosstalk in vascular inflammation |
| 773 | 1 | 8 | |g year:2025 |g elocationid:cvaf270 |g pages:1-16 |g extent:16 |a The complement: dendritic cell-endothelial cell crosstalk in vascular inflammation |
| 856 | 4 | 0 | |u https://doi.org/10.1093/cvr/cvaf270 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260205 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 129436038 |a Langer, Harald |m 129436038:Langer, Harald |d 60000 |d 61000 |e 60000PL129436038 |e 61000PL129436038 |k 0/60000/ |k 1/60000/61000/ |p 8 |y j | ||
| 998 | |g 129152196 |a Dürschmied, Daniel |m 129152196:Dürschmied, Daniel |d 60000 |d 61000 |e 60000PD129152196 |e 61000PD129152196 |k 0/60000/ |k 1/60000/61000/ |p 6 | ||
| 998 | |g 133214354 |a Stellos, Konstantinos |m 133214354:Stellos, Konstantinos |d 60000 |d 61500 |e 60000PS133214354 |e 61500PS133214354 |k 0/60000/ |k 1/60000/61500/ |p 5 | ||
| 998 | |g 1341529843 |a Bibli, Sofia-Iris |m 1341529843:Bibli, Sofia-Iris |d 60000 |d 65000 |e 60000PB1341529843 |e 65000PB1341529843 |k 0/60000/ |k 1/60000/65000/ |p 4 | ||
| 998 | |g 1064672426 |a Sauter, Reinhard Jörg |m 1064672426:Sauter, Reinhard Jörg |d 60000 |e 60000PS1064672426 |k 0/60000/ |p 3 | ||
| 998 | |g 1251518338 |a Sauter, Manuela |m 1251518338:Sauter, Manuela |d 60000 |d 61000 |e 60000PS1251518338 |e 61000PS1251518338 |k 0/60000/ |k 1/60000/61000/ |p 2 | ||
| 998 | |g 1389061078 |a Gregori, Serena |m 1389061078:Gregori, Serena |d 60000 |d 61000 |e 60000PG1389061078 |e 61000PG1389061078 |k 0/60000/ |k 1/60000/61000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1951210808 |e 4877048006 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"16 S."}],"recId":"1951210808","relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"306654393","disp":"The complement: dendritic cell-endothelial cell crosstalk in vascular inflammationCardiovascular research","pubHistory":["1.1967 -"],"origin":[{"publisher":"Oxford University Press ; Elsevier Science","publisherPlace":"Oxford ; Amsterdam [u.a.]","dateIssuedKey":"1967","dateIssuedDisp":"1967-"}],"note":["Gesehen am 01.12.2020"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"pages":"1-16","year":"2025","text":"(2025), Artikel-ID cvaf270, Seite 1-16","extent":"16"},"title":[{"title":"Cardiovascular research","title_sort":"Cardiovascular research"}],"id":{"zdb":["1499917-1"],"eki":["306654393"],"issn":["1755-3245"]}}],"person":[{"display":"Gregori, Serena","family":"Gregori","role":"aut","given":"Serena"},{"display":"Sauter, Manuela","role":"aut","given":"Manuela","family":"Sauter"},{"given":"Reinhard Jörg","role":"aut","family":"Sauter","display":"Sauter, Reinhard Jörg"},{"display":"Bibli, Sofia-Iris","role":"aut","given":"Sofia-Iris","family":"Bibli"},{"family":"Stellos","role":"aut","given":"Konstantinos","display":"Stellos, Konstantinos"},{"display":"Dürschmied, Daniel","family":"Dürschmied","given":"Daniel","role":"aut"},{"display":"Scharf, Rüdiger Eberhard","given":"Rüdiger Eberhard","role":"aut","family":"Scharf"},{"role":"aut","given":"Harald","family":"Langer","display":"Langer, Harald"}],"origin":[{"dateIssuedDisp":"18 December 2025","dateIssuedKey":"2025"}],"note":["Gesehen am 05.02.2026"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"The complement: dendritic cell-endothelial cell crosstalk in vascular inflammation","title_sort":"complement: dendritic cell-endothelial cell crosstalk in vascular inflammation"}],"name":{"displayForm":["Serena Gregori, Manuela Sauter, Reinhard Sauter, Sofia Iris Bibli, Konstantinos Stellos, Daniel Duerschmied, Rüdiger E. Scharf, and Harald F. Langer"]},"id":{"doi":["10.1093/cvr/cvaf270"],"eki":["1951210808"]}} | ||
| SRT | |a GREGORISERCOMPLEMENT1820 | ||