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Platelet counts and prognosis in heart failure with mildly reduced ejection fraction: results from a large-scaled registry

Objective - Platelets have been reported to promote heart failure (HF) through prothrombotic and proinflammatory pathways. The present study sought to investigate the prognostic impact of baseline platelet counts in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmr...

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Main Authors: Dudda, Jonas (Author) , Behnes, Michael (Author) , Weidner, Kathrin (Author) , Lau, Felix (Author) , Schmitt, Alexander (Author) , Reinhardt, Marielen (Author) , Abel, Noah (Author) , Bertsch, Thomas (Author) , Dürschmied, Daniel (Author) , Akın, Ibrahim (Author) , Schupp, Tobias (Author)
Format: Article (Journal)
Language:English
Published: 1 March 2026
In: International journal of cardiology
Year: 2026, Volume: 446, Pages: 1-10
ISSN:1874-1754
DOI:10.1016/j.ijcard.2025.134088
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ijcard.2025.134088
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527325011313
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Author Notes:Jonas Dudda, Michael Behnes, Kathrin Weidner, Felix Lau, Alexander Schmitt, Marielen Reinhardt, Noah Abel, Thomas Bertsch, Daniel Duerschmied, Ibrahim Akin, Tobias Schupp
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Summary:Objective - Platelets have been reported to promote heart failure (HF) through prothrombotic and proinflammatory pathways. The present study sought to investigate the prognostic impact of baseline platelet counts in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). - Background - The association of platelet counts and prognosis in patients with HFmrEF is not well studied. - Methods - Consecutive patients hospitalized with HFmrEF (ie, left ventricular ejection fraction 41-49 % and signs and/or symptoms of HF) were retrospectively included at one institution from 2016 to 2022. Clinical outcome was assessed according to baseline platelet counts comparing patients with 10-450/nL, 100- < 150/nL, 50- < 100/nL, <50/nL and > 450/nL. The primary endpoint was all-cause mortality at 30 months (median follow-up). The key secondary endpoint was HF-related rehospitalization at 30 months. - Results - From a total of 2151 consecutive patients with HFmrEF, the median platelet count was 253/nL (interquartile range (IQR) 196-287/nL). A baseline platelet count <50/nL (HR = 3.487; 95 % CI 2.111-5.760; p = 0.001) and 50- < 100/nL (HR = 1.565; 95 % CI 1.024-2.394; p = 0.036) was associated with increased risk of 30-months all-cause mortality compared to patients with normal platelet counts, which was still demonstrated after multivariable adjustments. In contrast, the presence of higher baseline platelet counts (>450/nL) was not associated with long-term all-cause mortality (HR = 1.140; 95 % CI 0.769-1.690; p = 0.515). Furthermore, no association between platelet count and the risk of HF-related rehospitalization was observed. - Conclusion - In patients hospitalized with HFmrEF, baseline platelet counts of <50/nL and 50- < 100/nL were independently associated with an increased risk of all-cause mortality at 30 months.
Item Description:Online veröffentlicht: 9. Dezember 2025, Artikelversion: 13. Dezember 2025
Gesehen am 09.02.2026
Physical Description:Online Resource
ISSN:1874-1754
DOI:10.1016/j.ijcard.2025.134088

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