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The sodium-glucose cotransporter-2 inhibitor canagliflozin alleviates endothelial dysfunction in a rat bypass model

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Ischemia/reperfusion (IR) injury during coronary artery bypass grafting surgery has detrimental impacts on endothelial integrity and function. Studies have suggested that canagliflozin (CANA) mitigates the risk of cardiovascular events, independently of diabetes. We hypothesized that the supplementa...

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Main Authors: Ma, Ming (Author) , Lian, Shuo (Author) , Kraft, Patricia (Author) , Mayer, Tobias (Author) , Sayour, Alex Ali (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author) , Korkmaz-İçöz, Sevil (Author)
Format: Article (Journal)
Language:English
Published: February 2026
In: Biochemical pharmacology
Year: 2026, Volume: 244, Pages: 1-12
ISSN:1873-2968
DOI:10.1016/j.bcp.2025.117601
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.bcp.2025.117601
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0006295225008664
Resolving-System, kostenfrei: https://doi.org/10.25673/122207
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Author Notes:Ming Ma, Shuo Lian, Patricia Kraft, Tobias Mayer, Alex Ali Sayour, Matthias Karck, Gábor Szabó, Sevil Korkmaz-Icöz
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Myofilament Ca2+ sensitivity correlates with left ventricular contractility during the progression of pressure overload-induced left ventricular myocardial hypertrophy in rats by Ruppert, Mihály (Author) , Korkmaz-İçöz, Sevil (Author) , Loganathan, Sivakkanan (Author) , Lehmann, Lorenz (Author) , Sayour, Alex Ali (Author) , Karck, Matthias (Author) , Szabó, Gábor (Author) ,


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