Buchumschlag

Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity

Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TM...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Moreno-Sanchez, Pilar M. (VerfasserIn) , Rezaeipour, Mahsa (VerfasserIn) , Inderberg, Else Marit (VerfasserIn) , Platten, Michael (VerfasserIn) , Golebiewska, Anna (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 2026
In: Nature cancer
Year: 2026, Jahrgang: 7, Pages: 29-42
ISSN:2662-1347
DOI:10.1038/s43018-025-01097-9
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s43018-025-01097-9
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s43018-025-01097-9
Volltext
Verfasserangaben:Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten & Anna Golebiewska

MARC

LEADER 00000naa a2200000 c 4500
001 196048382X
003 DE-627
005 20260210094046.0
007 cr uuu---uuuuu
008 260210s2026 xx |||||o 00| ||eng c
024 7 |a 10.1038/s43018-025-01097-9  |2 doi 
035 |a (DE-627)196048382X 
035 |a (DE-599)KXP196048382X 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Moreno-Sanchez, Pilar M.  |e VerfasserIn  |0 (DE-588)1389398110  |0 (DE-627)1960484648  |4 aut 
245 1 0 |a Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity  |c Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten & Anna Golebiewska 
264 1 |c January 2026 
300 |b Illustrationen, Diagramme 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online veröffentlicht: 8. Januar 2026 
500 |a Gesehen am 10.02.2026 
520 |a Plasticity is a hallmark of aggressive tumors, including glioblastoma (GBM), enabling tumor cells and the tumor microenvironment (TME) to adapt to diverse niches and evade treatment. Here, we discuss how innate and adaptive immune players cooperate in time and space to create an immunosuppressive TME that supports GBM growth and confers resistance to conventional treatments and immunotherapies. We highlight how therapeutic interventions reshape the TME, underscoring the need for targeted approaches to overcome resistance. We introduce the concepts of local TME priming and TME rewiring as necessary foundations for achieving more effective and durable clinical responses in the future. 
650 4 |a Cancer microenvironment 
650 4 |a CNS cancer 
650 4 |a Immune evasion 
650 4 |a Tumour immunology 
700 1 |a Rezaeipour, Mahsa  |e VerfasserIn  |4 aut 
700 1 |a Inderberg, Else Marit  |e VerfasserIn  |4 aut 
700 1 |a Platten, Michael  |d 1971-  |e VerfasserIn  |0 (DE-588)121627780  |0 (DE-627)081431848  |0 (DE-576)261969811  |4 aut 
700 1 |a Golebiewska, Anna  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Nature cancer  |d London : Nature Research, 2020  |g 7(2026) vom: Jan., Seite 29-42  |h Online-Ressource  |w (DE-627)1687330697  |w (DE-600)3005299-3  |x 2662-1347  |7 nnas  |a Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity 
773 1 8 |g volume:7  |g year:2026  |g month:01  |g pages:29-42  |g extent:14  |a Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity 
856 4 0 |u https://doi.org/10.1038/s43018-025-01097-9  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext  |7 1 
856 4 0 |u https://www.nature.com/articles/s43018-025-01097-9  |x Verlag  |z lizenzpflichtig  |3 Volltext  |7 1 
951 |a AR 
992 |a 20260210 
993 |a Article 
994 |a 2026 
998 |g 121627780  |a Platten, Michael  |m 121627780:Platten, Michael  |d 60000  |d 65100  |e 60000PP121627780  |e 65100PP121627780  |k 0/60000/  |k 1/60000/65100/  |p 4 
999 |a KXP-PPN196048382X  |e 4912227455 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Online veröffentlicht: 8. Januar 2026","Gesehen am 10.02.2026"],"title":[{"title_sort":"Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity","title":"Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunity"}],"origin":[{"dateIssuedDisp":"January 2026","dateIssuedKey":"2026"}],"person":[{"role":"aut","given":"Pilar M.","family":"Moreno-Sanchez","display":"Moreno-Sanchez, Pilar M."},{"display":"Rezaeipour, Mahsa","given":"Mahsa","role":"aut","family":"Rezaeipour"},{"display":"Inderberg, Else Marit","family":"Inderberg","given":"Else Marit","role":"aut"},{"display":"Platten, Michael","role":"aut","given":"Michael","family":"Platten"},{"display":"Golebiewska, Anna","role":"aut","given":"Anna","family":"Golebiewska"}],"relHost":[{"disp":"Immunosuppressive mechanisms and therapeutic interventions shaping glioblastoma immunityNature cancer","recId":"1687330697","physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["3005299-3"],"eki":["1687330697"],"issn":["2662-1347"]},"part":{"year":"2026","pages":"29-42","extent":"14","volume":"7","text":"7(2026) vom: Jan., Seite 29-42"},"title":[{"title":"Nature cancer","title_sort":"Nature cancer"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 14.01.20"],"origin":[{"dateIssuedKey":"2020","publisherPlace":"London","dateIssuedDisp":"2020-","publisher":"Nature Research"}],"pubHistory":["Volume 1, Issue 1, (January 2020)-"]}],"physDesc":[{"noteIll":"Illustrationen, Diagramme","extent":"14 S."}],"recId":"196048382X","id":{"eki":["196048382X"],"doi":["10.1038/s43018-025-01097-9"]},"name":{"displayForm":["Pilar M. Moreno-Sanchez, Mahsa Rezaeipour, Else Marit Inderberg, Michael Platten & Anna Golebiewska"]}} 
SRT |a MORENOSANCIMMUNOSUPP2026 

Ähnliche Einträge