Repeatability and reproducibility of maximum diameter measurements of prostate lesions on MRI with repositioning and variation of imaging sequences: a test-retest study
Objectives - To assess variability of maximum diameter measurements of prostate lesions in MRI assessing patient repositioning, rater and sequence effects. - Methods - Forty-two patients were included retrospectively, who received a clinical bi−/multiparametric prostate MRI examination and agreed to...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 2026
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| In: |
Magnetic resonance imaging
Year: 2026, Volume: 127, Pages: 1-11 |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/j.mri.2025.110578 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.mri.2025.110578 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0730725X25002620 
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| Author Notes: | Kevin Sun Zhang, Philip Alexander Glemser, Christian Jan Oliver Neelsen, Markus Wennmann, Lukas Thomas Rotkopf, Nils Netzer, Clara Meinzer, Thomas Hielscher, Vivienn Weru, Magdalena Görtz, Albrecht Stenzinger, Markus Hohenfellner, Heinz-Peter Schlemmer, David Bonekamp |
| Summary: | Objectives - To assess variability of maximum diameter measurements of prostate lesions in MRI assessing patient repositioning, rater and sequence effects. - Methods - Forty-two patients were included retrospectively, who received a clinical bi−/multiparametric prostate MRI examination and agreed to have the T2-weighted (T2WI) and diffusion weighted-imaging (DWI) sequences scanned twice. Maximum diameter measurements of prostate lesions mentioned in the clinical radiologist reports were performed by four readers in multiple reading sessions for determination of inter-sequence (between two DWI sequences), inter-scan (between clinical and additional scan), intra-rater and inter-rater variability. The primary calculated metrics were the repeatability and reproducibility coefficient (RC/RDC), including pooled RC/RDC. - Results - Variability measured by RCs/RDCs was lowest for measurements obtained within the same reading session, with inter-scan RCs up to 5.6 mm/6.5 mm for T2WI/DWI, pooled RCs of 4.8 mm/5.8 mm, respectively, and inter-sequence RDCs of 5.4 mm-5.9 mm, pooled RDC 5.8 mm. Measurements performed in separate reading sessions demonstrated significantly higher variability for both settings in the majority of cases (RCs: up to 10.9 mm/11.7 mm/10.2 mm for T2WI/DWI/inter-sequence, p ≤ 0.002), pooled RCs/RDCs 9.2 mm-9.9 mm. Measurements necessarily generated in different reading sessions, i.e., intra-rater or inter-rater, demonstrated high variability (RCs/RDCs up to 11.4 mm/11.5 mm for T2WI/DWI). - Conclusions - Prostate lesion measurements demonstrate considerable variability. When measured in one reading session by one rater, lesion diameter differences below the pooled RCs of 4.8 mm, 95 %-CI [3.9, 5.6] for T2WI and 5.8 mm, 95 %-CI [4.7, 7.1] for DWI should not necessarily assumed to be true biological change, as these differences may result from measurement- or repositioning-based variability alone. Caution needs to be taken assessing size changes. |
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| Item Description: | Online verfügbar: 27. November 2025, Artikelversion: 4. Dezember 2025 Gesehen am 12.02.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1873-5894 |
| DOI: | 10.1016/j.mri.2025.110578 |