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Real-world characteristics, treatment patterns, and outcomes in advanced HER2 (ERBB2)-mutant non-small cell lung cancer: a retrospective study of single centers in France and Germany

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Purpose - Human epidermal growth factor receptor 2 (HER2 [ERBB2]) gene mutations occur in ∼3-5% of non-small cell lung cancer (NSCLC) cases and are associated with poor prognosis. However, real-world data on patients with HER2-mutant (HER2m) NSCLC are needed. - Methods - This retrospective, observat...

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Main Authors: Christopoulos, Petros (Author) , Assmann, Christin (Author) , Zhang, Lirong (Author) , Dunton, Kyle (Author) , Ali, Ahmed (Author) , Berktas, Mehmet (Author) , Delmastro, Lisa (Author) , Strübing, Alessandria (Author) , Xiong, Yan (Author) , Lay-Flurrie, Sarah (Author) , Hindocha, Pooja (Author) , Mehdikhanova, Tarana (Author) , Girard, Nicolas (Author)
Format: Article (Journal)
Language:English
Published: December 2025
In: Clinical therapeutics
Year: 2025, Volume: 47, Issue: 12, Pages: 1161-1169
ISSN:1879-114X
DOI:10.1016/j.clinthera.2025.09.019
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.clinthera.2025.09.019
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0149291825003455
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Author Notes:Petros Christopoulos, Christin Assmann, Lirong Zhang, Kyle Dunton, Ahmed Ali, Mehmet Berktas, Lisa Delmastro, Alessandria Strübing, Yan Xiong, Sarah Lay-Flurrie, Pooja Hindocha, Tarana Mehdikhanova, Nicolas Girard
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The role of zongertinib, a highly selective tyrosine kinase inhibitor, in targeting HER2-mutant NSCLC: a bench-to-bedside review by Heymach, John (Author) , Popat, Sanjay (Author) , Smit, Egbert F. (Author) , Christopoulos, Petros (Author) , Planchard, David (Author) , Yoshida, Tatsuya (Author) , Zugazagoitia, Jon (Author) , Yu, Yan (Author) , Wilding, Birgit (Author) ,


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Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors by Sobol, Benjamin (Author) , Azzam Nieto, Osama (Author) , Eberlein, Emily Lara (Author) , Scherr, Anna-Lena (Author) , Ismail, Lars (Author) , Keßler, Annika (Author) , Nader, Luisa (Author) , Schwab, Maximilian (Author) , Hoffmeister-Wittmann, Paula (Author) , Schmitt, Nathalie (Author) , Jäger, Dirk (Author) , Welte, Stefan Ezechiel (Author) , Seidensaal, Katharina (Author) , Christopoulos, Petros (Author) , Heilig, Christoph E. (Author) , Kriegsmann, Katharina (Author) , Fröhling, Stefan (Author) , Kriegsmann, Mark (Author) , Heß, Jochen (Author) , Köhler, Bruno Christian (Author) ,


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Efficacy of immune checkpoint inhibitors alone or in combination with chemotherapy in NSCLC harboring ERBB2 mutations by Saalfeld, Felix (Author) , Wenzel, Carina (Author) , Christopoulos, Petros (Author) , Merkelbach-Bruse, Sabine (Author) , Reissig, Timm M. (Author) , Laßmann, Silke (Author) , Thiel, Sebastian (Author) , Stratmann, Jan A. (Author) , Marienfeld, Ralf (Author) , Berger, Johannes (Author) , Desuki, Alexander (Author) , Velthaus, Janna-Lisa (Author) , Kauffmann-Guerrero, Diego (Author) , Stenzinger, Albrecht (Author) , Michels, Sebastian (Author) , Herold, Thomas (Author) , Kramer, Michael (Author) , Herold, Sylvia (Author) , Tufman, Amanda (Author) , Loges, Sonja (Author) , Alt, Jürgen (Author) , Joosten, Maria (Author) , Schmidtke-Schrezenmeier, Gerlinde (Author) , Sebastian, Martin (Author) , Stephan-Falkenau, Susann (Author) , Waller, Cornelius F. (Author) , Wiesweg, Marcel (Author) , Wolf, Jürgen (Author) , Thomas, Michael (Author) , Aust, Daniela E. (Author) , Wermke, Martin (Author) ,


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