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Early distant progression in adult Histone-3 K27-altered diffuse midline gliomas

H3 K27-altered diffuse midline glioma (DMG) is a molecularly defined, highly aggressive tumor entity since the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). It has been most extensively characterized in children and adolescents and...

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Main Authors: Graßl, Niklas (Author) , Suwala, Abigail Kora (Author) , Keßler, Tobias (Author) , Bunse, Lukas (Author) , Mildenberger, Iris (Author) , Breckwoldt, Michael O. (Author) , Ratliff, Miriam (Author) , Brehmer, Stefanie (Author) , Herold-Mende, Christel (Author) , Etminan, Nima (Author) , Wick, Wolfgang (Author) , Sahm, Felix (Author) , Platten, Michael (Author) , Sahm, Katharina (Author)
Format: Article (Journal)
Language:English
Published: 13 January 2026
In: Journal of neuro-oncology
Year: 2026, Volume: 176, Pages: 1-10
ISSN:1573-7373
DOI:10.1007/s11060-025-05238-z
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s11060-025-05238-z
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Author Notes:Niklas Grassl, Abigail K. Suwala, Tobias Kessler, Lukas Bunse, Iris Mildenberger, Michael O. Breckwoldt, Miriam Ratliff, Stefanie Brehmer, Christel Herold-Mende, Nima Etminan, Wolfgang Wick, Felix Sahm, Michael Platten, Katharina Sahm
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Summary:H3 K27-altered diffuse midline glioma (DMG) is a molecularly defined, highly aggressive tumor entity since the 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). It has been most extensively characterized in children and adolescents and continues to pose significant challenges to treating physicians due to its growth along the midline structures of the brain and its ability to progress distantly leading to poor prognosis. Clinical and molecular determinants of distant progression and its impact on patient survival particularly in adults have not been thoroughly characterized.
Item Description:Gesehen am 16.02.2026
Physical Description:Online Resource
ISSN:1573-7373
DOI:10.1007/s11060-025-05238-z

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