Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease
Serum uromodulin (SUmod) and carbamylated albumin (C-Alb) are emerging biomarkers for chronic kidney disease (CKD) progression and mortality. SUmod reflects tubular health, while C-Alb is associated with excretory kidney function, CKD progression, and cardiovascular (CV) mortality. We hypothesized t...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 December 2025
|
| In: |
Clinical chemistry
Year: 2025, Pages: 1-11 |
| ISSN: | 1530-8561 |
| DOI: | 10.1093/clinchem/hvaf166 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/clinchem/hvaf166
|
| Verfasserangaben: | Clara Daschner, Marcus E. Kleber, Anders H. Berg, Faeq Husain-Syed, Jürgen E. Scherberich, Bernhard K. Krämer, Winfried März, and Babak Yazdani |
MARC
| LEADER | 00000naa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1961327317 | ||
| 003 | DE-627 | ||
| 005 | 20260217123408.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260217s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/clinchem/hvaf166 |2 doi | |
| 035 | |a (DE-627)1961327317 | ||
| 035 | |a (DE-599)KXP1961327317 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Daschner, Clara |d 1992- |e VerfasserIn |0 (DE-588)1282580884 |0 (DE-627)1838232656 |4 aut | |
| 245 | 1 | 0 | |a Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease |c Clara Daschner, Marcus E. Kleber, Anders H. Berg, Faeq Husain-Syed, Jürgen E. Scherberich, Bernhard K. Krämer, Winfried März, and Babak Yazdani |
| 264 | 1 | |c 16 December 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 16. Dezember 2025 | ||
| 500 | |a Gesehen am 17.02.2026 | ||
| 520 | |a Serum uromodulin (SUmod) and carbamylated albumin (C-Alb) are emerging biomarkers for chronic kidney disease (CKD) progression and mortality. SUmod reflects tubular health, while C-Alb is associated with excretory kidney function, CKD progression, and cardiovascular (CV) mortality. We hypothesized that the combined use of these markers would improve mortality risk assessments.We analyzed the associations of C-Alb and SUmod levels with the estimated glomerular filtration rate (eGFR) along with their combined predictive value for assessing mortality in 3316 participants of the Ludwigshafen Risk and Cardiovascular Health study showing mid to high CV risk.SUmod correlated moderately with eGFR (ρ = 0.39, P < 0.001) and weakly and inversely with C-Alb (ρ = −0.19, P < 0.001); C-Alb negatively correlated with eGFR (ρ = −0.38, P < 0.001). Patients in the C-Alb high/SUmod low group had the highest mortality risk [hazard ratio (HR)= 3.30; 95% CI, 2.73-3.99], which remained significant after adjustment for confounders, including eGFR (HR = 1.89; 95% CI, 1.24-1.89). In risk-prediction models for all-cause mortality, adding SUmod increased the area under the curve (AUC) from 0.728 to 0.746 (P < 0.001), C-Alb to 0.738 (P = 0.026), and both combined to 0.751 (P < 0.001). For CV mortality, AUC rose from 0.698 to 0.721 with SUmod (P < 0.001), to 0.711 with C-Alb (P = 0.018), and to 0.727 (P = 0.004) in the combined model.SUmod and C-Alb levels yield complementary insights into kidney function, biology, and mortality risk beyond eGFR. Low SUmod/high C-Alb revealed the highest mortality risk, even after multivariate adjustment.DRKS00032641. | ||
| 700 | 1 | |a Kleber, Marcus E. |d 1974- |e VerfasserIn |0 (DE-588)1030135177 |0 (DE-627)734830440 |0 (DE-576)377941379 |4 aut | |
| 700 | 1 | |a Berg, Anders H |e VerfasserIn |4 aut | |
| 700 | 1 | |a Husain-Syed, Faeq |e VerfasserIn |4 aut | |
| 700 | 1 | |a Scherberich, Jürgen E |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krämer, Bernhard |d 1957- |e VerfasserIn |0 (DE-588)14017589X |0 (DE-627)70358927X |0 (DE-576)314926852 |4 aut | |
| 700 | 1 | |a März, Winfried |d 1958- |e VerfasserIn |0 (DE-588)1027603599 |0 (DE-627)729463605 |0 (DE-576)373454635 |4 aut | |
| 700 | 1 | |a Yazdani, Babak |d 1985- |e VerfasserIn |0 (DE-588)1216966516 |0 (DE-627)1728612462 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical chemistry |d Washington, DC : American Association for Clinical Chemistry, 1955 |g (2025), Artikel-ID hvaf166, Seite 1-11 |h Online-Ressource |w (DE-627)266883117 |w (DE-600)1468161-4 |w (DE-576)075146401 |x 1530-8561 |7 nnas |a Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease |
| 773 | 1 | 8 | |g year:2025 |g elocationid:hvaf166 |g pages:1-11 |g extent:11 |a Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease |
| 856 | 4 | 0 | |u https://doi.org/10.1093/clinchem/hvaf166 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260217 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1216966516 |a Yazdani, Babak |m 1216966516:Yazdani, Babak |d 910000 |d 950000 |d 950950 |e 910000PY1216966516 |e 950000PY1216966516 |e 950950PY1216966516 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 8 |y j | ||
| 998 | |g 1027603599 |a März, Winfried |m 1027603599:März, Winfried |d 910000 |d 910100 |d 60000 |d 61400 |e 910000PM1027603599 |e 910100PM1027603599 |e 60000PM1027603599 |e 61400PM1027603599 |k 0/910000/ |k 1/910000/910100/ |k 0/60000/ |k 1/60000/61400/ |p 7 | ||
| 998 | |g 14017589X |a Krämer, Bernhard |m 14017589X:Krämer, Bernhard |d 60000 |d 61400 |e 60000PK14017589X |e 61400PK14017589X |k 0/60000/ |k 1/60000/61400/ |p 6 | ||
| 998 | |g 1030135177 |a Kleber, Marcus E. |m 1030135177:Kleber, Marcus E. |d 60000 |d 61400 |e 60000PK1030135177 |e 61400PK1030135177 |k 0/60000/ |k 1/60000/61400/ |p 2 | ||
| 998 | |g 1282580884 |a Daschner, Clara |m 1282580884:Daschner, Clara |d 910000 |d 950000 |d 950950 |e 910000PD1282580884 |e 950000PD1282580884 |e 950950PD1282580884 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 1 |x j | ||
| 999 | |a KXP-PPN1961327317 |e 4918811000 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Clara Daschner, Marcus E. Kleber, Anders H. Berg, Faeq Husain-Syed, Jürgen E. Scherberich, Bernhard K. Krämer, Winfried März, and Babak Yazdani"]},"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}],"language":["eng"],"recId":"1961327317","type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"corporate":[{"display":"American Association of Clinical Chemists","role":"isb"}],"title":[{"title":"Clinical chemistry","title_sort":"Clinical chemistry","subtitle":"journal of the American Association for Clinical Chemistry ; international journal of laboratory medicine and molecular diagnostics"}],"note":["Gesehen am 26.08.2021"],"disp":"Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney diseaseClinical chemistry","origin":[{"dateIssuedDisp":"1955-","publisher":"American Association for Clinical Chemistry ; Oxford University Press","dateIssuedKey":"1955","publisherPlace":"Washington, DC ; Oxford"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"id":{"zdb":["1468161-4"],"eki":["266883117"],"issn":["1530-8561"]},"part":{"extent":"11","year":"2025","text":"(2025), Artikel-ID hvaf166, Seite 1-11","pages":"1-11"},"pubHistory":["1.1955 -"],"recId":"266883117"}],"note":["Veröffentlicht: 16. Dezember 2025","Gesehen am 17.02.2026"],"person":[{"family":"Daschner","role":"aut","given":"Clara","display":"Daschner, Clara"},{"role":"aut","given":"Marcus E.","family":"Kleber","display":"Kleber, Marcus E."},{"role":"aut","given":"Anders H","family":"Berg","display":"Berg, Anders H"},{"role":"aut","given":"Faeq","family":"Husain-Syed","display":"Husain-Syed, Faeq"},{"family":"Scherberich","role":"aut","given":"Jürgen E","display":"Scherberich, Jürgen E"},{"display":"Krämer, Bernhard","given":"Bernhard","role":"aut","family":"Krämer"},{"given":"Winfried","role":"aut","family":"März","display":"März, Winfried"},{"role":"aut","given":"Babak","family":"Yazdani","display":"Yazdani, Babak"}],"title":[{"title":"Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease","title_sort":"Association of serum uromodulin and carbamylated albumin with all-cause and cardiovascular mortality in patients with no or mild chronic kidney disease"}],"origin":[{"dateIssuedDisp":"16 December 2025","dateIssuedKey":"2025"}],"id":{"eki":["1961327317"],"doi":["10.1093/clinchem/hvaf166"]}} | ||
| SRT | |a DASCHNERCLASSOCIATIO1620 | ||