Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases
Background: With the development of highly effective disease-modifying treatments, vaccinations are becoming increasingly important in people with neurological autoimmune diseases. However, questions regarding the safety and efficacy of vaccinations under immunotherapy remain. - Objective: To provid...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January-December 2025
|
| In: |
Therapeutic advances in neurological disorders
Year: 2025, Jahrgang: 18, Pages: 1-40 |
| ISSN: | 1756-2864 |
| DOI: | 10.1177/17562864251396006 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/17562864251396006
|
| Verfasserangaben: | Muriel Schraad, Mathias Mäurer, Anke Salmen, Tobias Ruck, Timo Uphaus, Vinzenz Fleischer, Felix Luessi, Maria Protopapa, Falk Steffen, Nicholas Hanuscheck, Katrin Pape, Tobias Brummer, Josef Shin, Thomas Korn, Luisa Klotz, Jan D. Lünemann, Marc Pawlitzki, Martin S. Weber, Antonios Bayas, Brigitte Wildemann, Hans-Peter Hartung, Florian Then Bergh, Clemens Warnke, Uwe K. Zettl, Achim Berthele, Aiden Haghikia, Ralf Linker, Hayrettin Tumani, Sven G. Meuth, Bernhard Hemmer, Heinz Wiendl, Tania Kümpfel, Ralf Gold, Stefan Bittner and Frauke Zipp |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1961855488 | ||
| 003 | DE-627 | ||
| 005 | 20260220094110.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260220s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/17562864251396006 |2 doi | |
| 035 | |a (DE-627)1961855488 | ||
| 035 | |a (DE-599)KXP1961855488 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schraad, Muriel Carolyn |d 1994- |e VerfasserIn |0 (DE-588)131493032X |0 (DE-627)1877075531 |4 aut | |
| 245 | 1 | 0 | |a Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases |c Muriel Schraad, Mathias Mäurer, Anke Salmen, Tobias Ruck, Timo Uphaus, Vinzenz Fleischer, Felix Luessi, Maria Protopapa, Falk Steffen, Nicholas Hanuscheck, Katrin Pape, Tobias Brummer, Josef Shin, Thomas Korn, Luisa Klotz, Jan D. Lünemann, Marc Pawlitzki, Martin S. Weber, Antonios Bayas, Brigitte Wildemann, Hans-Peter Hartung, Florian Then Bergh, Clemens Warnke, Uwe K. Zettl, Achim Berthele, Aiden Haghikia, Ralf Linker, Hayrettin Tumani, Sven G. Meuth, Bernhard Hemmer, Heinz Wiendl, Tania Kümpfel, Ralf Gold, Stefan Bittner and Frauke Zipp |
| 264 | 1 | |c January-December 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 40 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 12. Dezember 2025 | ||
| 500 | |a Gesehen am 20.02.2026 | ||
| 520 | |a Background: With the development of highly effective disease-modifying treatments, vaccinations are becoming increasingly important in people with neurological autoimmune diseases. However, questions regarding the safety and efficacy of vaccinations under immunotherapy remain. - Objective: To provide recommendations on types and timing of vaccinations for people with neuroimmunological diseases under different immunotherapies. - Design: Our study presents a German evidence-based expert consensus on vaccination under immunotherapies in neurological autoimmune diseases. - Methods: Based on literature research, a consortium of experts evaluated the quality of evidence, integrated clinical experience, and responded to a questionnaire determining an agreement (>75%) on statements concerning vaccination upon immune therapies in neuroimmunological diseases. - Results: The specific humoral and cellular response to vaccination can be compromised under alemtuzumab, azathioprine, cladribine, cyclophosphamide, CD19/CD20 antibodies (inebilizumab, ocrelizumab, ofatumumab, rituximab, ublituximab), dimethyl fumarate/diroximel fumarate, FcRn inhibitors (efgartigimod, rozanolixizumab), complement C5 inhibitors (eculizumab, ravulizumab, zilucoplan), interleukin-6 receptor antibodies (tocilizumab, satralizumab), intravenous immunoglobulins, long-term steroid administration, methotrexate, mitoxantrone, mycophenolate mofetil, tacrolimus, teriflunomide, tumor necrosis factor-α blockers, and sphingosine-1-phosphate receptor modulators (fingolimod, ozanimod, ponesimod, siponimod), as well as after autologous stem cell transplantation. The lymphocyte count can have an influence here. Overall, it is generally advisable to complete vaccination before starting immunotherapy. However, in the case of an active inflammatory disease course with possible irreversible neurological deficits, a delay in therapy initiation until immunization has been completed cannot be justified. The application of live vaccines is contraindicated for most therapies and is only recommended after a strict risk-benefit assessment. - Conclusion: Vaccinations are necessary for individuals on immunotherapy to reduce the risk of infections and the associated risk of worsening neurological autoimmune diseases. However, the humoral and cellular vaccination response may be impaired under immunotherapy necessitating close monitoring. Here, we provide applicable recommendations to optimize immunization for individuals receiving immunotherapy due to a neurological autoimmune disease. | ||
| 700 | 1 | |a Mäurer, Mathias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Salmen, Anke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruck, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Uphaus, Timo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fleischer, Vinzenz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luessi, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Protopapa, Maria |e VerfasserIn |4 aut | |
| 700 | 1 | |a Steffen, Falk |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hanuscheck, Nicholas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pape, Katrin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brummer, Tobias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shin, Josef |e VerfasserIn |4 aut | |
| 700 | 1 | |a Korn, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klotz, Luisa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lünemann, Jan D. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pawlitzki, Marc |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Martin S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bayas, Antonios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wildemann, Brigitte |e VerfasserIn |0 (DE-588)110203844 |0 (DE-627)510150004 |0 (DE-576)171831330 |4 aut | |
| 700 | 1 | |a Hartung, Hans-Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Then Bergh, Florian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Warnke, Clemens |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zettl, Uwe K. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Berthele, Achim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Haghikia, Aiden |e VerfasserIn |4 aut | |
| 700 | 1 | |a Linker, Ralf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tumani, Hayrettin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meuth, Sven G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hemmer, Bernhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wiendl, Heinz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kümpfel, Tania |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gold, Ralf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bittner, Stefan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zipp, Frauke |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Therapeutic advances in neurological disorders |d London [u.a.] : Sage, 2008 |g 18(2025) vom: Jan./Dez., Artikel-ID 17562864251396006, Seite 1-40 |h Online-Ressource |w (DE-627)573753849 |w (DE-600)2442245-9 |w (DE-576)305897357 |x 1756-2864 |7 nnas |a Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases |
| 773 | 1 | 8 | |g volume:18 |g year:2025 |g month:01/12 |g elocationid:17562864251396006 |g pages:1-40 |g extent:40 |a Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases |
| 856 | 4 | 0 | |u https://doi.org/10.1177/17562864251396006 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260220 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 110203844 |a Wildemann, Brigitte |m 110203844:Wildemann, Brigitte |d 910000 |d 911100 |d 50000 |e 910000PW110203844 |e 911100PW110203844 |e 50000PW110203844 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 20 | ||
| 999 | |a KXP-PPN1961855488 |e 4920518528 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Muriel Schraad, Mathias Mäurer, Anke Salmen, Tobias Ruck, Timo Uphaus, Vinzenz Fleischer, Felix Luessi, Maria Protopapa, Falk Steffen, Nicholas Hanuscheck, Katrin Pape, Tobias Brummer, Josef Shin, Thomas Korn, Luisa Klotz, Jan D. Lünemann, Marc Pawlitzki, Martin S. Weber, Antonios Bayas, Brigitte Wildemann, Hans-Peter Hartung, Florian Then Bergh, Clemens Warnke, Uwe K. Zettl, Achim Berthele, Aiden Haghikia, Ralf Linker, Hayrettin Tumani, Sven G. Meuth, Bernhard Hemmer, Heinz Wiendl, Tania Kümpfel, Ralf Gold, Stefan Bittner and Frauke Zipp"]},"physDesc":[{"noteIll":"Illustrationen","extent":"40 S."}],"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"January-December 2025"}],"person":[{"display":"Schraad, Muriel Carolyn","role":"aut","given":"Muriel Carolyn","family":"Schraad"},{"display":"Mäurer, Mathias","given":"Mathias","role":"aut","family":"Mäurer"},{"family":"Salmen","display":"Salmen, Anke","given":"Anke","role":"aut"},{"family":"Ruck","given":"Tobias","role":"aut","display":"Ruck, Tobias"},{"family":"Uphaus","display":"Uphaus, Timo","given":"Timo","role":"aut"},{"family":"Fleischer","display":"Fleischer, Vinzenz","role":"aut","given":"Vinzenz"},{"family":"Luessi","display":"Luessi, Felix","role":"aut","given":"Felix"},{"family":"Protopapa","role":"aut","given":"Maria","display":"Protopapa, Maria"},{"family":"Steffen","display":"Steffen, Falk","given":"Falk","role":"aut"},{"given":"Nicholas","role":"aut","display":"Hanuscheck, Nicholas","family":"Hanuscheck"},{"family":"Pape","given":"Katrin","role":"aut","display":"Pape, Katrin"},{"family":"Brummer","display":"Brummer, Tobias","given":"Tobias","role":"aut"},{"family":"Shin","role":"aut","given":"Josef","display":"Shin, Josef"},{"family":"Korn","display":"Korn, Thomas","role":"aut","given":"Thomas"},{"display":"Klotz, Luisa","given":"Luisa","role":"aut","family":"Klotz"},{"family":"Lünemann","given":"Jan D.","role":"aut","display":"Lünemann, Jan D."},{"family":"Pawlitzki","given":"Marc","role":"aut","display":"Pawlitzki, Marc"},{"given":"Martin S.","role":"aut","display":"Weber, Martin S.","family":"Weber"},{"family":"Bayas","display":"Bayas, Antonios","role":"aut","given":"Antonios"},{"family":"Wildemann","display":"Wildemann, Brigitte","role":"aut","given":"Brigitte"},{"family":"Hartung","given":"Hans-Peter","role":"aut","display":"Hartung, Hans-Peter"},{"family":"Then Bergh","given":"Florian","role":"aut","display":"Then Bergh, Florian"},{"given":"Clemens","role":"aut","display":"Warnke, Clemens","family":"Warnke"},{"display":"Zettl, Uwe K.","given":"Uwe K.","role":"aut","family":"Zettl"},{"display":"Berthele, Achim","given":"Achim","role":"aut","family":"Berthele"},{"family":"Haghikia","role":"aut","given":"Aiden","display":"Haghikia, Aiden"},{"family":"Linker","display":"Linker, Ralf","given":"Ralf","role":"aut"},{"family":"Tumani","given":"Hayrettin","role":"aut","display":"Tumani, Hayrettin"},{"family":"Meuth","role":"aut","given":"Sven G.","display":"Meuth, Sven G."},{"family":"Hemmer","given":"Bernhard","role":"aut","display":"Hemmer, Bernhard"},{"given":"Heinz","role":"aut","display":"Wiendl, Heinz","family":"Wiendl"},{"family":"Kümpfel","role":"aut","given":"Tania","display":"Kümpfel, Tania"},{"display":"Gold, Ralf","role":"aut","given":"Ralf","family":"Gold"},{"family":"Bittner","given":"Stefan","role":"aut","display":"Bittner, Stefan"},{"display":"Zipp, Frauke","given":"Frauke","role":"aut","family":"Zipp"}],"id":{"eki":["1961855488"],"doi":["10.1177/17562864251396006"]},"note":["Online veröffentlicht: 12. Dezember 2025","Gesehen am 20.02.2026"],"title":[{"title_sort":"Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases","title":"Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseases"}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"origin":[{"publisherPlace":"London [u.a.]","publisher":"Sage","dateIssuedKey":"2008","dateIssuedDisp":"2008-"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Cellular and humoral vaccination response under immunotherapies - German consensus on vaccination strategies in neurological autoimmune diseasesTherapeutic advances in neurological disorders","title":[{"title":"Therapeutic advances in neurological disorders","title_sort":"Therapeutic advances in neurological disorders"}],"id":{"eki":["573753849"],"zdb":["2442245-9"],"issn":["1756-2864"]},"pubHistory":["1.2008 -"],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"573753849","part":{"year":"2025","pages":"1-40","volume":"18","extent":"40","text":"18(2025) vom: Jan./Dez., Artikel-ID 17562864251396006, Seite 1-40"}}],"recId":"1961855488"} | ||
| SRT | |a SCHRAADMURCELLULARAN2025 | ||