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Talquetamab plus daratumumab for the treatment of relapsed or refractory multiple myeloma in the TRIMM-2 study

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Talquetamab, a G protein-coupled receptor class C group 5 member D-targeting bispecific antibody for relapsed/refractory multiple myeloma (R/R MM), plus daratumumab, may lead to deeper and more durable responses than either therapy alone. In the phase 1b TRIMM-2 study, patients with R/R MM (at least...

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Main Authors: Chari, Ajai (Author) , van de Donk, Niels W. C. J. (Author) , Dholaria, Bhagirathbhai (Author) , Weisel, Katja (Author) , Mateos, María-Victoria (Author) , Goldschmidt, Hartmut (Author) , Martin, Thomas G. (Author) , Morillo, Daniel (Author) , Reece, Donna (Author) , Rodríguez-Otero, Paula (Author) , Bhutani, Manisha (Author) , D’Souza, Anita (Author) , Oriol, Albert (Author) , Rosiñol, Laura (Author) , Bahlis, Nizar J. (Author) , Vishwamitra, Deeksha (Author) , Skerget, Sheri (Author) , Verona, Raluca I. (Author) , Bakshi, Kalpana (Author) , Kang, Lijuan (Author) , Prior, Thomas J. (Author) , Vandenberk, Lien (Author) , Tolbert, Jaszianne (Author) , Lee, Sangmin (Author) , Smit, M. Damiette (Author) , Wäsch, Ralph (Author)
Format: Article (Journal)
Language:English
Published: December 11 2025
In: Blood
Year: 2025, Volume: 146, Issue: 24, Pages: 2902-2913
ISSN:1528-0020
DOI:10.1182/blood.2025029360
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2025029360
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Author Notes:Ajai Chari, Niels W.C.J. van de Donk, Bhagirathbhai Dholaria, Katja Weisel, María-Victoria Mateos, Hartmut Goldschmidt, Thomas G. Martin, Daniel Morillo, Donna Reece, Paula Rodríguez-Otero, Manisha Bhutani, Anita D’Souza, Albert Oriol, Laura Rosiñol, Nizar J. Bahlis, Deeksha Vishwamitra, Sheri Skerget, Raluca I. Verona, Kalpana Bakshi, Lijuan Kang, Thomas J. Prior, Lien Vandenberk, Jaszianne Tolbert, Sangmin Lee, M. Damiette Smit, Ralph Wäsch
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Addition of cyclophosphamide on insufficient response to pomalidomide and dexamethasone: results of the phase II PERSPECTIVE multiple myeloma trial by Weisel, Katja (Author) , Mai, Elias K. (Author) , Seckinger, Anja (Author) , Kunz, Christina (Author) , Benner, Axel (Author) , Hose, Dirk (Author) , Jauch, Anna (Author) , Goldschmidt, Hartmut (Author) ,


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