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Nasal respiration modulates pain perception via the olfactory bulb-anterior cingulate cortex circuit

Breath regulation has been shown to reduce pain and anxiety-like emotions in humans, but the underlying neural mechanisms are still unclear. Here, we demonstrate that nasal respiratory sensory deprivation (Triton X-100) reduces the respiration-entrained rhythm (RR) transmitted from the olfactory bul...

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Hauptverfasser: Cheng, Ruixue (VerfasserIn) , Wang, Yuxue (VerfasserIn) , Dou, Chunyan (VerfasserIn) , Gu, Song (VerfasserIn) , Tang, Weixiang (VerfasserIn) , Chen, Chen (VerfasserIn) , Chen, Ke (VerfasserIn) , Cui, Shuai (VerfasserIn) , Zhong, Weiwei (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 21 November 2025
In: iScience
Year: 2025, Jahrgang: 28, Heft: 11, Pages: 1-15, e1-e5
ISSN:2589-0042
DOI:10.1016/j.isci.2025.113766
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.isci.2025.113766
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004225020279
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Verfasserangaben:Ruixue Cheng, Yuxue Wang, Chunyan Dou, Song Gu, Weixiang Tang, Chen Chen, Ke Chen, Shuai Cui, and Weiwei Zhong
Beschreibung
Zusammenfassung:Breath regulation has been shown to reduce pain and anxiety-like emotions in humans, but the underlying neural mechanisms are still unclear. Here, we demonstrate that nasal respiratory sensory deprivation (Triton X-100) reduces the respiration-entrained rhythm (RR) transmitted from the olfactory bulb (OB) to the anterior cingulate cortex (ACC), ultimately exerting an antinociceptive effect in a mouse model of neuropathic pain. Specifically, optogenetics, in vivo fiber photometry, viral tracing, and immunofluorescence staining revealed that nasal respiratory sensory deprivation activates GABAergic projections from the OB to the ACC and inhibits glutamatergic (Glu) neurons in the ACC. Chemogenetic activation or inhibition of the OB-ACCGlu pathway leads to nociceptive hypersensitivity or exerts antinociceptive effects, respectively. Similarly, the activation or inhibition of ACC-projecting OBGABA neurons reduces neuropathic pain or induces nociceptive sensitization. Taken together, our findings offer new insights into therapeutic approaches for pain relief through nasal breathing.
Beschreibung:Online verfügbar 14 October 2025, Version des Artikels 30 October 2025
Gesehen am 23.02.2026
Beschreibung:Online Resource
ISSN:2589-0042
DOI:10.1016/j.isci.2025.113766

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