Perioperative laboratory profiles predict complications after extensive head and neck reconstruction: a proof-of-concept study
IntroductionSurgical reconstruction of head and neck defects after oncological resection is a complex procedure often associated with unpredictable postoperative complications. Hence, laboratory parameter profiles are of considerable interest as potential perioperative predictors.MethodsThis retrosp...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
02 January 2026
|
| In: |
Frontiers in oncology
Year: 2026, Jahrgang: 15, Pages: 1-11 |
| ISSN: | 2234-943X |
| DOI: | 10.3389/fonc.2025.1724846 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3389/fonc.2025.1724846 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1724846/full 
|
| Verfasserangaben: | Tatjana Khromov, Simon Breier, Ulrich Stefenelli, Boris Schminke, Julie Schanz, Andreas Fischer, Henning Schliephake and Phillipp Brockmeyer |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 196239512X | ||
| 003 | DE-627 | ||
| 005 | 20260224111053.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260224s2026 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fonc.2025.1724846 |2 doi | |
| 035 | |a (DE-627)196239512X | ||
| 035 | |a (DE-599)KXP196239512X | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Khromov, Tatjana |e VerfasserIn |0 (DE-588)1391152956 |0 (DE-627)1962395561 |4 aut | |
| 245 | 1 | 0 | |a Perioperative laboratory profiles predict complications after extensive head and neck reconstruction |b a proof-of-concept study |c Tatjana Khromov, Simon Breier, Ulrich Stefenelli, Boris Schminke, Julie Schanz, Andreas Fischer, Henning Schliephake and Phillipp Brockmeyer |
| 264 | 1 | |c 02 January 2026 | |
| 300 | |b Diagramme | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.02.2026 | ||
| 520 | |a IntroductionSurgical reconstruction of head and neck defects after oncological resection is a complex procedure often associated with unpredictable postoperative complications. Hence, laboratory parameter profiles are of considerable interest as potential perioperative predictors.MethodsThis retrospective study analyzed a comprehensive set of laboratory parameters in 233 patients with oral squamous cell carcinoma (OSCC) who underwent tumor resection and reconstruction.ResultsThe overall complication rate was 30%, with wound dehiscence (12.4%), pulmonary embolism (PE, 11.6%), and surgical revision (10.3%) being the most common complications. Dynamic analysis of perioperative laboratory parameters from one week before to 49 days after surgery revealed that patients who developed complications showed less pronounced decreases in hemoglobin, hematocrit, and erythrocyte levels. These patients also exhibited altered coagulation and electrolyte profiles. Statistical analysis using logistic regression identified hematocrit slope as independent predictor. Meanwhile, random forest modeling highlighted INR and aPTT as key markers. Subgroup analysis showed that PE, the most clinically significant complication, was associated with abnormal potassium, urea, and protein profiles. Whereas a therapy-related increase in aPTT was observed postoperatively, INR alterations were already evident preoperatively. Conversely, local complications such as wound dehiscence, surgical revision, and graft failure were more strongly associated with deteriorating hematological parameters.DiscussionGiven their multifactorial nature, influenced by comorbidities, tumor biology, and perioperative management, these findings highlight the need for longitudinal laboratory monitoring and prospective validation in controlled settings. Integrating dynamic laboratory trends into multimodal prediction models may facilitate earlier risk stratification and improve individualized perioperative management in head and neck reconstructive surgery. | ||
| 650 | 4 | |a head and neck surgery | |
| 650 | 4 | |a perioperative laboratory trends | |
| 650 | 4 | |a postoperative complications | |
| 650 | 4 | |a reconstructive and plastic surgery | |
| 650 | 4 | |a risk stratification | |
| 700 | 1 | |a Breier, Simon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stefenelli, Ulrich |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schminke, Boris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schanz, Julie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fischer, Andreas |d 1976- |e VerfasserIn |0 (DE-588)124869955 |0 (DE-627)367234300 |0 (DE-576)294543511 |4 aut | |
| 700 | 1 | |a Schliephake, Henning |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brockmeyer, Phillipp |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in oncology |d Lausanne : Frontiers Media, 2011 |g 15(2026), Artikel-ID 1724846, Seite 1-11 |h Online-Ressource |w (DE-627)684965518 |w (DE-600)2649216-7 |w (DE-576)35841184X |x 2234-943X |7 nnas |a Perioperative laboratory profiles predict complications after extensive head and neck reconstruction a proof-of-concept study |
| 773 | 1 | 8 | |g volume:15 |g year:2026 |g elocationid:1724846 |g pages:1-11 |g extent:11 |a Perioperative laboratory profiles predict complications after extensive head and neck reconstruction a proof-of-concept study |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fonc.2025.1724846 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1724846/full |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 951 | |a AR | ||
| 992 | |a 20260224 | ||
| 993 | |a Article | ||
| 994 | |a 2026 | ||
| 998 | |g 124869955 |a Fischer, Andreas |m 124869955:Fischer, Andreas |d 60000 |d 63300 |e 60000PF124869955 |e 63300PF124869955 |k 0/60000/ |k 1/60000/63300/ |p 6 | ||
| 999 | |a KXP-PPN196239512X |e 4921711461 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","given":"Tatjana","display":"Khromov, Tatjana","family":"Khromov"},{"family":"Breier","display":"Breier, Simon","given":"Simon","role":"aut"},{"display":"Stefenelli, Ulrich","family":"Stefenelli","role":"aut","given":"Ulrich"},{"given":"Boris","role":"aut","family":"Schminke","display":"Schminke, Boris"},{"display":"Schanz, Julie","family":"Schanz","role":"aut","given":"Julie"},{"family":"Fischer","display":"Fischer, Andreas","given":"Andreas","role":"aut"},{"given":"Henning","role":"aut","family":"Schliephake","display":"Schliephake, Henning"},{"display":"Brockmeyer, Phillipp","family":"Brockmeyer","role":"aut","given":"Phillipp"}],"language":["eng"],"title":[{"title_sort":"Perioperative laboratory profiles predict complications after extensive head and neck reconstruction","subtitle":"a proof-of-concept study","title":"Perioperative laboratory profiles predict complications after extensive head and neck reconstruction"}],"note":["Gesehen am 24.02.2026"],"relHost":[{"origin":[{"dateIssuedKey":"2011","publisher":"Frontiers Media","dateIssuedDisp":"2011-","publisherPlace":"Lausanne"}],"disp":"Perioperative laboratory profiles predict complications after extensive head and neck reconstruction a proof-of-concept studyFrontiers in oncology","part":{"text":"15(2026), Artikel-ID 1724846, Seite 1-11","extent":"11","year":"2026","pages":"1-11","volume":"15"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"684965518","type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["2011 -"],"note":["Gesehen am 07.11.13"],"title":[{"title_sort":"Frontiers in oncology","title":"Frontiers in oncology"}],"id":{"issn":["2234-943X"],"eki":["684965518"],"zdb":["2649216-7"]},"language":["eng"]}],"recId":"196239512X","origin":[{"dateIssuedDisp":"02 January 2026","dateIssuedKey":"2026"}],"id":{"eki":["196239512X"],"doi":["10.3389/fonc.2025.1724846"]},"name":{"displayForm":["Tatjana Khromov, Simon Breier, Ulrich Stefenelli, Boris Schminke, Julie Schanz, Andreas Fischer, Henning Schliephake and Phillipp Brockmeyer"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"11 S.","noteIll":"Diagramme"}]} | ||
| SRT | |a KHROMOVTATPERIOPERAT0220 | ||