Prostate cancer detection in younger men: a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trial
The optimal approach for prostate cancer (PC) screening, including the ideal starting age and most effective diagnostic method, remains under investigation. We evaluated the diagnostic performance of magnetic resonance imaging (MRI)-targeted biopsy (TBx) and systematic biopsy (SBx) in detecting clin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2025
|
| In: |
European urology
Year: 2025, Jahrgang: 88, Heft: 3, Pages: 240-244 |
| ISSN: | 1873-7560 |
| DOI: | 10.1016/j.eururo.2025.05.020 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.eururo.2025.05.020 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0302283825002982 
|
| Verfasserangaben: | Rouvier Al-Monajjed, Matthias Boschheidgen, Jale Lakes, Agne Krilaviciute, Jan-Philipp Radtke, Heinz-Peter Schlemmer, David Bonekamp, Kathleen Herkommer, Matthias Jahnen, Jürgen E. Gschwend, Daniel Düx, Frank Wacker, Marcus R. Makowski, Andreas Sauter, Markus A. Kuczyk, Nina Harke, Jürgen Debus, Christoph Grott, Christian Arsov, Petra Seibold, Boris Hadaschik, Frederik Giesel, Glenn Kristiansen, Gerald Antoch, Nikolaus Becker, Rudolf Kaaks, Lars Schimmöller, Peter Albers |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1962560201 | ||
| 003 | DE-627 | ||
| 005 | 20260225092422.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 260225s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.eururo.2025.05.020 |2 doi | |
| 035 | |a (DE-627)1962560201 | ||
| 035 | |a (DE-599)KXP1962560201 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Monajjed, Rouvier Al- |d 1989- |e VerfasserIn |0 (DE-588)1057939234 |0 (DE-627)795551851 |0 (DE-576)413941302 |4 aut | |
| 245 | 1 | 0 | |a Prostate cancer detection in younger men |b a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trial |c Rouvier Al-Monajjed, Matthias Boschheidgen, Jale Lakes, Agne Krilaviciute, Jan-Philipp Radtke, Heinz-Peter Schlemmer, David Bonekamp, Kathleen Herkommer, Matthias Jahnen, Jürgen E. Gschwend, Daniel Düx, Frank Wacker, Marcus R. Makowski, Andreas Sauter, Markus A. Kuczyk, Nina Harke, Jürgen Debus, Christoph Grott, Christian Arsov, Petra Seibold, Boris Hadaschik, Frederik Giesel, Glenn Kristiansen, Gerald Antoch, Nikolaus Becker, Rudolf Kaaks, Lars Schimmöller, Peter Albers |
| 264 | 1 | |c September 2025 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.02.2026 | ||
| 520 | |a The optimal approach for prostate cancer (PC) screening, including the ideal starting age and most effective diagnostic method, remains under investigation. We evaluated the diagnostic performance of magnetic resonance imaging (MRI)-targeted biopsy (TBx) and systematic biopsy (SBx) in detecting clinically significant PC (csPC) in men aged 45-50 yr in PROBASE, a prospective, randomized trial of a risk-adapted screening strategy. A total of 525 participants with elevated prostate-specific antigen (≥3 ng/ml) underwent MRI followed by biopsy. Of the 209 PC cases detected, 148 (71%) were csPC. SBx identified 94% of csPC cases, while TBx detected 74% (p ≤ 0.05). SBx also diagnosed significantly more low-grade PCs than TBx (p < 0.001). These findings suggest that relying solely on MRI-TBx may lead to underdiagnosis of csPC. Combining SBx with TBx remains the most effective strategy for early detection of PC in young men undergoing screening. Future research should explore optimization strategies to reduce unnecessary biopsies while maintaining high detection rates for csPC. This trial is registered on the ISRCTN registry as ISRCTN37591328 (https://www.isrctn.com/ISRCTN37591328). The study protocol can be accessed at https://doi.org/10.1016/j.eururo.2013.05.022. | ||
| 650 | 4 | |a Fusion biopsy | |
| 650 | 4 | |a Magnetic resonance imaging | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a Prostate-specific antigen | |
| 650 | 4 | |a Risk-adapted screening | |
| 650 | 4 | |a Ultrasound | |
| 700 | 1 | |a Boschheidgen, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lakes, Jale |e VerfasserIn |4 aut | |
| 700 | 1 | |a Krilaviciute, Agne |d 1988- |e VerfasserIn |0 (DE-588)1141206986 |0 (DE-627)898965772 |0 (DE-576)415191602 |4 aut | |
| 700 | 1 | |a Radtke, Jan Philipp |d 1985- |e VerfasserIn |0 (DE-588)1020328290 |0 (DE-627)688118089 |0 (DE-576)360178170 |4 aut | |
| 700 | 1 | |a Schlemmer, Heinz-Peter |d 1961- |e VerfasserIn |0 (DE-588)1025559967 |0 (DE-627)722927142 |0 (DE-576)17334805X |4 aut | |
| 700 | 1 | |a Bonekamp, David |d 1977- |e VerfasserIn |0 (DE-588)128868104 |0 (DE-627)383668581 |0 (DE-576)297371797 |4 aut | |
| 700 | 1 | |a Herkommer, Kathleen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jahnen, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gschwend, Jürgen E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Düx, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wacker, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |a Makowski, Marcus R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sauter, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuczyk, Markus A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harke, Nina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Grott, Christoph A. |e VerfasserIn |0 (DE-588)1370610807 |0 (DE-627)1929730225 |4 aut | |
| 700 | 1 | |a Arsov, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Seibold, Petra Beate |d 1981- |e VerfasserIn |0 (DE-588)1022470523 |0 (DE-627)71698962X |0 (DE-576)362814635 |4 aut | |
| 700 | 1 | |a Hadaschik, Boris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giesel, Frederik |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kristiansen, Glenn |e VerfasserIn |4 aut | |
| 700 | 1 | |a Antoch, Gerald |e VerfasserIn |4 aut | |
| 700 | 1 | |a Becker, Nikolaus |d 1950- |e VerfasserIn |0 (DE-588)124780962 |0 (DE-627)706711084 |0 (DE-576)186605765 |4 aut | |
| 700 | 1 | |a Kaaks, Rudolf |d 1960- |e VerfasserIn |0 (DE-588)172809223 |0 (DE-627)697739562 |0 (DE-576)133665518 |4 aut | |
| 700 | 1 | |a Schimmöller, Lars |e VerfasserIn |4 aut | |
| 700 | 1 | |a Albers, Peter |d 1963- |e VerfasserIn |0 (DE-588)130499714 |0 (DE-627)502596864 |0 (DE-576)30256361X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European urology |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 88(2025), 3 vom: Sept., Seite 240-244 |h Online-Ressource |w (DE-627)300191596 |w (DE-600)1482253-2 |w (DE-576)099718103 |x 1873-7560 |7 nnas |a Prostate cancer detection in younger men a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trial |
| 773 | 1 | 8 | |g volume:88 |g year:2025 |g number:3 |g month:09 |g pages:240-244 |g extent:5 |a Prostate cancer detection in younger men a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trial |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.eururo.2025.05.020 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |7 1 |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0302283825002982 |x Verlag |z lizenzpflichtig |3 Volltext |7 1 |
| 951 | |a AR | ||
| 992 | |a 20260225 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 172809223 |a Kaaks, Rudolf |m 172809223:Kaaks, Rudolf |d 50000 |e 50000PK172809223 |k 0/50000/ |p 26 | ||
| 998 | |g 124780962 |a Becker, Nikolaus |m 124780962:Becker, Nikolaus |d 50000 |e 50000PB124780962 |k 0/50000/ |p 25 | ||
| 998 | |g 1370610807 |a Grott, Christoph A. |m 1370610807:Grott, Christoph A. |d 910000 |d 911400 |e 910000PG1370610807 |e 911400PG1370610807 |k 0/910000/ |k 1/910000/911400/ |p 18 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 17 | ||
| 998 | |g 128868104 |a Bonekamp, David |m 128868104:Bonekamp, David |d 50000 |e 50000PB128868104 |k 0/50000/ |p 7 | ||
| 998 | |g 1025559967 |a Schlemmer, Heinz-Peter |m 1025559967:Schlemmer, Heinz-Peter |d 50000 |e 50000PS1025559967 |k 0/50000/ |p 6 | ||
| 998 | |g 1020328290 |a Radtke, Jan Philipp |m 1020328290:Radtke, Jan Philipp |d 50000 |e 50000PR1020328290 |k 0/50000/ |p 5 | ||
| 999 | |a KXP-PPN1962560201 |e 4922158685 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"5 S."}],"person":[{"family":"Monajjed","role":"aut","given":"Rouvier Al-","display":"Monajjed, Rouvier Al-"},{"role":"aut","family":"Boschheidgen","display":"Boschheidgen, Matthias","given":"Matthias"},{"given":"Jale","display":"Lakes, Jale","family":"Lakes","role":"aut"},{"role":"aut","family":"Krilaviciute","given":"Agne","display":"Krilaviciute, Agne"},{"role":"aut","family":"Radtke","given":"Jan Philipp","display":"Radtke, Jan Philipp"},{"role":"aut","family":"Schlemmer","display":"Schlemmer, Heinz-Peter","given":"Heinz-Peter"},{"family":"Bonekamp","role":"aut","given":"David","display":"Bonekamp, David"},{"role":"aut","family":"Herkommer","given":"Kathleen","display":"Herkommer, Kathleen"},{"given":"Matthias","display":"Jahnen, Matthias","role":"aut","family":"Jahnen"},{"given":"Jürgen E.","display":"Gschwend, Jürgen E.","family":"Gschwend","role":"aut"},{"family":"Düx","role":"aut","display":"Düx, Daniel","given":"Daniel"},{"family":"Wacker","role":"aut","given":"Frank","display":"Wacker, Frank"},{"given":"Marcus R.","display":"Makowski, Marcus R.","family":"Makowski","role":"aut"},{"display":"Sauter, Andreas","given":"Andreas","family":"Sauter","role":"aut"},{"family":"Kuczyk","role":"aut","given":"Markus A.","display":"Kuczyk, Markus A."},{"display":"Harke, Nina","given":"Nina","family":"Harke","role":"aut"},{"display":"Debus, Jürgen","given":"Jürgen","family":"Debus","role":"aut"},{"display":"Grott, Christoph A.","given":"Christoph A.","family":"Grott","role":"aut"},{"given":"Christian","display":"Arsov, Christian","role":"aut","family":"Arsov"},{"display":"Seibold, Petra Beate","given":"Petra Beate","role":"aut","family":"Seibold"},{"given":"Boris","display":"Hadaschik, Boris","role":"aut","family":"Hadaschik"},{"given":"Frederik","display":"Giesel, Frederik","family":"Giesel","role":"aut"},{"display":"Kristiansen, Glenn","given":"Glenn","family":"Kristiansen","role":"aut"},{"role":"aut","family":"Antoch","given":"Gerald","display":"Antoch, Gerald"},{"display":"Becker, Nikolaus","given":"Nikolaus","role":"aut","family":"Becker"},{"role":"aut","family":"Kaaks","display":"Kaaks, Rudolf","given":"Rudolf"},{"given":"Lars","display":"Schimmöller, Lars","family":"Schimmöller","role":"aut"},{"family":"Albers","role":"aut","display":"Albers, Peter","given":"Peter"}],"relHost":[{"pubHistory":["Nachgewiesen 2.1976 -"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Prostate cancer detection in younger men a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trialEuropean urology","origin":[{"dateIssuedKey":"1976","dateIssuedDisp":"1976-","publisherPlace":"Amsterdam [u.a.] ; Basel","publisher":"Elsevier Science ; Karger"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"extent":"5","year":"2025","issue":"3","text":"88(2025), 3 vom: Sept., Seite 240-244","pages":"240-244","volume":"88"},"language":["eng"],"title":[{"title_sort":"European urology","title":"European urology","subtitle":"official organ of the European Association of Urology, the European Organization for Research and Treatment of Cancer - Genito-Urinary Group, the European Society for Urological Oncology and Endocrinology"}],"note":["Ungezählte Beil. bis 40.2001: Supplement"],"id":{"eki":["300191596"],"zdb":["1482253-2"],"issn":["1873-7560","1421-993X"]},"recId":"300191596"}],"name":{"displayForm":["Rouvier Al-Monajjed, Matthias Boschheidgen, Jale Lakes, Agne Krilaviciute, Jan-Philipp Radtke, Heinz-Peter Schlemmer, David Bonekamp, Kathleen Herkommer, Matthias Jahnen, Jürgen E. Gschwend, Daniel Düx, Frank Wacker, Marcus R. Makowski, Andreas Sauter, Markus A. Kuczyk, Nina Harke, Jürgen Debus, Christoph Grott, Christian Arsov, Petra Seibold, Boris Hadaschik, Frederik Giesel, Glenn Kristiansen, Gerald Antoch, Nikolaus Becker, Rudolf Kaaks, Lars Schimmöller, Peter Albers"]},"note":["Gesehen am 25.02.2026"],"title":[{"title":"Prostate cancer detection in younger men","title_sort":"Prostate cancer detection in younger men","subtitle":"a comparative analysis of systematic and magnetic resonance imaging-targeted biopsy in the PROBASE trial"}],"id":{"eki":["1962560201"],"doi":["10.1016/j.eururo.2025.05.020"]},"recId":"1962560201","origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"September 2025"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"]} | ||
| SRT | |a MONAJJEDROPROSTATECA2025 | ||