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Restoration of CB1 receptor function in hippocampal GABAergic neurons rescues memory deficits in Huntington’s disease models

Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are well-established hallmarks of Huntington’s disease (HD). As a result, significant research efforts have focused on targeting the eCBS to alleviate motor disturbances associated with the d...

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Main Authors: Di Franco, Nadia (Author) , Bengoetxea de Tena, Iker (Author) , Sanchez-Ruiz, Andrea (Author) , Pereda-Velarde, Alba (Author) , Enfedaque, Ferran (Author) , Gónzalez-Arias, Candela (Author) , Rio, Lluis Maria Miquel (Author) , Bortolozzi, Analia (Author) , Rodriguez-Puertas, Rafael (Author) , Costas-Insua, Carlos (Author) , Molina-Porcel, Laura (Author) , Vazquez-Oliver, Anna (Author) , Ozaita, Andres (Author) , Guzmán, Manuel (Author) , Perea, Gertrudis (Author) , Ginés, Silvia (Author)
Format: Article (Journal)
Language:English
Published: 2025
In: Translational neurodegeneration
Year: 2025, Volume: 14, Pages: 1-22
ISSN:2047-9158
DOI:10.1186/s40035-025-00500-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40035-025-00500-w
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Author Notes:Nadia Di Franco, Iker Bengoetxea de Tena, Andrea Sanchez-Ruiz, Alba Pereda-Velarde, Ferran Enfedaque, Candela Gónzalez-Arias, Lluis Maria Miquel Rio, Analia Bortolozzi, Rafael Rodriguez-Puertas, Carlos Costas-Insua, Laura Molina-Porcel, Anna Vazquez-Oliver, Andres Ozaita, Manuel Guzmán, Gertrudis Perea and Silvia Ginés
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Summary:Dysregulation of the endocannabinoid system (eCBS) and the loss of CB1 receptors (CB1R) in the basal ganglia are well-established hallmarks of Huntington’s disease (HD). As a result, significant research efforts have focused on targeting the eCBS to alleviate motor disturbances associated with the disease. Beyond its role in motor control, the eCBS is a complex signaling network critically involved in regulating learning and memory. Despite this, the potential involvement of eCBS dysfunction in the cognitive decline characteristic of HD, often manifested well before motor dysfunction, has remained largely unexplored.
Item Description:Online veröffentlicht: 25. August 2025
Gesehen am 25.02.2026
Physical Description:Online Resource
ISSN:2047-9158
DOI:10.1186/s40035-025-00500-w

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