When heme is low, copper kills cancer: leading edge
Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acute myeloid leukemia cells by cuproptosis.
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| Main Author: | |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
8 January 2026
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| In: |
Cell
Year: 2026, Volume: 189, Issue: 1, Pages: 3-5 |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2025.12.010 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2025.12.010 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867425014230 
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| Author Notes: | Andreas Linkermann |
MARC
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| 520 | |a Heme carries oxygen and is critical for the control of redox reactions. In this issue of Cell, Lewis and Gruber et al. demonstrate how low concentrations of heme destabilize complex IV of the respiratory chain to release copper and kill acute myeloid leukemia cells by cuproptosis. | ||
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