High versus low pneumoperitoneum PressUre for parenchymal transection in minimally invasive major liver surgery (PPULS): a non-inferiority, multicenter, randomized, controlled trial

Low pneumoperitoneum pressure (LPP) lowers the incidence of CO2 embolisms in minimally invasive liver resections (MILR), while higher pneumoperitoneum pressure (HPP) reduces intraoperative blood loss. This contradiction necessitates careful pressure management especially in major liver resections wh...

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Bibliographic Details

Main Authors:	Giehl-Brown, Esther (Author) , Khajeh, Elias (Author) , Dehne, Sarah (Author) , Czigány, Zoltán (Author) , Gutzeit, Oliver (Author) , Neuhaus, Christopher (Author) , Riediger, Carina (Author) , Birgin, Emrullah (Author) , Rahbari, Nuh (Author) , D’Hondt, Mathieu (Author) , Lurje, Georg (Author) , Weigand, Markus A. (Author) , Michalski, Christoph (Author) , Mehrabi, Arianeb (Author) , Kahlert, Christoph (Author)
Format:	Article (Journal)
Language:	English
Published:	01 December 2025
In:	Trials Year: 2025, Volume: 26, Issue: 1
ISSN:	1468-6694
DOI:	10.1186/s13063-025-09269-9
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13063-025-09269-9 Verlag, kostenfrei, Volltext: https://link.springer.com/article/10.1186/s13063-025-09269-9
Author Notes:	Esther Giehl-Brown, Elias Khajeh, Sarah Dehne, Zoltan Czigany, Oliver Gutzeit, Christopher Neuhaus, Carina Riediger, Emrullah Birgin, Nuh Rahbari, Mathieu D’Hondt, Georg Lurje, Markus Weigand, Christoph Michalski, Arianeb Mehrabi and Christoph Kahlert