Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors

Sensing of viral pathogens by RIG-I-like receptors (RLRs) requires their priming via dephosphorylation mediated by the protein phosphatase 1 regulatory subunit 12 C (R12C), which is activated upon virus-induced actin rearrangements. Here, we show that the HIV-1 accessory protein Nef prevents R12C-me...

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Bibliographic Details
Main Authors:	Laliberté, Alexandre (Author) , Prelli Bozzo, Caterina (Author) , Acharya, Dhiraj (Author) , De Luna, Aurora (Author) , Hirschenberger, Maximilian (Author) , Zhu, Junji (Author) , Volcic, Meta (Author) , Stolp-Rastätter, Bettina (Author) , Rodriguez Quinteros, Cristina (Author) , Fackler, Oliver Till (Author) , Gack, Michaela U. (Author) , Sparrer, Konstantin M. J. (Author) , Kirchhoff, Frank (Author)
Format:	Article (Journal)
Language:	English
Published:	07 December 2025
In:	Nature Communications Year: 2025, Volume: 16, Pages: 1-15
ISSN:	2041-1723
DOI:	10.1038/s41467-025-67028-5
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-025-67028-5 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-025-67028-5
Author Notes:	Alexandre Laliberté, Caterina Prelli Bozzo, Dhiraj Acharya, Aurora De Luna, Maximilian Hirschenberger, Junji Zhu, Meta Volcic, Bettina Stolp, Cristina M. Rodriguez-Quinteros, Oliver T. Fackler, Michaela U. Gack, Konstantin M.J. Sparrer & Frank Kirchhoff

The pathogenicity factor Nef in HIV-1 infection by Obermaier, Benedikt (Author)

2022

Book/Monograph Thesis

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo by Stolp-Rastätter, Bettina (Author) , Imle, Andrea (Author) , Fackler, Oliver Till (Author) ,

in: Proceedings of the National Academy of Sciences of the United States of America, 109 (2012), 45, Seite 18541-18546

Article (Journal) Online Resource

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction by Schmidt, Sarah (Author) , Fritz, Joëlle (Author) , Bitzegeio, Julia (Author) , Fackler, Oliver Till (Author) , Keppler, Oliver Till (Author) ,

in: mBio, 2 (2011), 3, Artikel-ID e00036-11, Seite 1-13

Article (Journal) Online Resource

Nef stabilizes actin to prevent HIV-1 sensing by RIG-I-like receptors

The pathogenicity factor Nef in HIV-1 infection by Obermaier, Benedikt (Author)

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo by Stolp-Rastätter, Bettina (Author) , Imle, Andrea (Author) , Fackler, Oliver Till (Author) ,

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction by Schmidt, Sarah (Author) , Fritz, Joëlle (Author) , Bitzegeio, Julia (Author) , Fackler, Oliver Till (Author) , Keppler, Oliver Till (Author) ,

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