The Therapeutic potential of farm dust extracts in a mouse model of eosinophilic inflammation
Background Asthma affects over 355 million people globally and poses a major healthcare burden. While corticosteroids remain a cornerstone of treatment, their side effects highlight the need for additional therapeutic strategies. Environmental exposures such as traditional farm dust have been linked...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 October 2025
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| In: |
Allergy
Year: 2025, Pages: 1-20 |
| ISSN: | 1398-9995 |
| DOI: | 10.1111/all.70121 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/all.70121 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.70121?getft_integrator=clarivate&src=getftr&utm_source=clarivate 
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| Author Notes: | Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertuz, Christoph Mueller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Onder Yildirim, Erika von Mutius |
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| 245 | 1 | 4 | |a The Therapeutic potential of farm dust extracts in a mouse model of eosinophilic inflammation |c Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertuz, Christoph Mueller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Onder Yildirim, Erika von Mutius |
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| 520 | |a Background Asthma affects over 355 million people globally and poses a major healthcare burden. While corticosteroids remain a cornerstone of treatment, their side effects highlight the need for additional therapeutic strategies. Environmental exposures such as traditional farm dust have been linked to protection against asthma and allergies. This study investigated the therapeutic potential of farm dust extract (FDE) in a murine model of allergic asthma when administered after sensitization and during allergen challenge, mimicking a secondary prevention or early interventional treatment approach.Methods We used an ovalbumin (OVA)-induced asthma model to evaluate FDE effects on airway eosinophilia, airway hyperresponsiveness (AHR), mucus production, and IgE levels. Mechanistic studies assessed regulatory T cells (Tregs), dendritic cell phenotype, epithelial barrier integrity, and cytokine signaling. Complementary experiments were performed in peripheral blood mononuclear cells (PBMCs) from asthmatic donors.Results FDE significantly reduced airway inflammation and AHR, with secondary prevention effects comparable to systemic dexamethasone. FDE enhanced Treg frequency and CTLA-4 expression, modulated dendritic cell MHC-II and PD-L1 expression, and promoted an immunoregulatory environment. It also restored epithelial barrier integrity and increased IL-33 release, supporting Treg activation. In asthmatic PBMCs, FDE increased Tregs, reduced Th2 cells, and suppressed CIITA, suggesting similar immune-regulatory effects. Interactions among IL-33, amphiregulin (AREG), and Tregs highlighted a mechanism reinforcing immune-epithelial homeostasis.Conclusion FDE administered after sensitization and during allergen challenge mitigated key asthma features in mice and showed translational potential in human cells, supporting its development as a novel, environmentally derived immunomodulatory strategy. | ||
| 650 | 4 | |a AIRWAY INFLAMMATION | |
| 650 | 4 | |a AMPHIREGULIN | |
| 650 | 4 | |a asthma | |
| 650 | 4 | |a ASTHMA | |
| 650 | 4 | |a epithelial barrier | |
| 650 | 4 | |a EPITHELIAL-CELLS | |
| 650 | 4 | |a EXPRESSION | |
| 650 | 4 | |a farm dust extract | |
| 650 | 4 | |a GLUCOCORTICOIDS | |
| 650 | 4 | |a IL-33 | |
| 650 | 4 | |a IMMUNITY | |
| 650 | 4 | |a MURINE MODEL | |
| 650 | 4 | |a prophylactic intervention | |
| 650 | 4 | |a regulatory T cells | |
| 650 | 4 | |a REGULATORY T-CELLS | |
| 650 | 4 | |a Th2 inflammation | |
| 700 | 1 | |a Omony, Jimmy |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tan, Xiaomei |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Mueller, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ragab, Mohab |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Nawroth, Janna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kapellos, Theodore S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rankl, Bettina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Yildirim, Ali Onder |e VerfasserIn |4 aut | |
| 700 | 1 | |a von Mutius, Erika |e VerfasserIn |4 aut | |
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