Evaluation of the TARGET score for MRI-based detection of prostate cancer recurrence in patients treated with HIFU hemiablation
Purpose - To evaluate diagnostic performance and inter-reader agreement of the Transatlantic Recommendations for Prostate Gland Evaluation with MRI after Focal Therapy (TARGET). - Methods - This retrospective, multi-center study included patients who underwent high-intensity focused ultrasound (HIFU...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 2026
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| In: |
European journal of radiology
Year: 2026, Jahrgang: 195, Pages: 1-7 |
| ISSN: | 1872-7727 |
| DOI: | 10.1016/j.ejrad.2025.112572 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ejrad.2025.112572 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S0720048X25006588 
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| Verfasserangaben: | Constantin Ehrengut, Nilüfer Deniz Alberalar, Toni Franz, Lars-Christian Horn, Andreas Blana, Boris Hadaschik, Jens-Uwe Stolzenburg, Heinz Peter Schlemmer, Sebastian Ebel, Timm°Denecke, Roman Ganzer, Alexander Schaudinn |
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| 245 | 1 | 0 | |a Evaluation of the TARGET score for MRI-based detection of prostate cancer recurrence in patients treated with HIFU hemiablation |c Constantin Ehrengut, Nilüfer Deniz Alberalar, Toni Franz, Lars-Christian Horn, Andreas Blana, Boris Hadaschik, Jens-Uwe Stolzenburg, Heinz Peter Schlemmer, Sebastian Ebel, Timm°Denecke, Roman Ganzer, Alexander Schaudinn |
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| 520 | |a Purpose - To evaluate diagnostic performance and inter-reader agreement of the Transatlantic Recommendations for Prostate Gland Evaluation with MRI after Focal Therapy (TARGET). - Methods - This retrospective, multi-center study included patients who underwent high-intensity focused ultrasound (HIFU) hemiablation for localized prostate cancer (PCa), with follow-up multiparametric MRI (mpMRI) at 12 months and subsequent biopsy (reference standard). Three radiologists independently assessed the mpMRIs using the TARGET score (treated prostate side) and the PI-RADS score (v2.1, untreated side). Diagnostic performance metrics and area under the receiver operating characteristic curves (AUC) were computed for any-/clinically significant-PCa (cs-PCa) and two scoring thresholds (3 vs. 4). Inter-reader-agreement was analyzed using Fleiss к. - Results - Of all 40 patients included, 23 had biopsy-proven recurrent PCa in 26 lesions, with seven lesions harboring cs-PCa (5/7 on the treated side). TARGET showed moderate to high sensitivity (Reader 1-3: 60-100 %), high NPV (91-100 %) but lower specificity (54-69 %) and PPV (16-27 %) in the detection of cs-PCa, given a scoring threshold of ≥ 3. The diagnostic performance for cs-PCa (AUC: 0.57-0.79) exceeded that of any-PCa (0.54-0.64). PI-RADS showed an overall moderate efficacy in any-/cs-PCa-detection (untreated prostate side, AUC: 0.52-0.60). Overall inter-reader agreement was moderate (TARGET к = 0.60-0.64, PI-RADS к = 0.54-0.55). - Conclusions - The strength of the TARGET score was its high NPV, implying its potential to rule out cs-PCa. However, the moderate sensitivity and specificity, low PPV and moderate inter-reader agreement indicate a limited reliability of TARGET to consistently identify cs-PCa recurrence. The generalizability of these findings is restricted by the overall small sample size. | ||
| 650 | 4 | |a Focal therapy | |
| 650 | 4 | |a Hemiablation | |
| 650 | 4 | |a HIFU | |
| 650 | 4 | |a Multiparametric MRI | |
| 650 | 4 | |a Prostate cancer | |
| 650 | 4 | |a TARGET | |
| 700 | 1 | |a Alberalar, Nilüfer Deniz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Franz, Toni |e VerfasserIn |4 aut | |
| 700 | 1 | |a Horn, Lars-Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blana, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hadaschik, Boris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stolzenburg, Jens-Uwe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlemmer, Heinz-Peter |d 1961- |e VerfasserIn |0 (DE-588)1025559967 |0 (DE-627)722927142 |0 (DE-576)17334805X |4 aut | |
| 700 | 1 | |a Ebel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Denecke, Timm |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ganzer, Roman |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schaudinn, Alexander |e VerfasserIn |4 aut | |
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