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  title info:
    title: O-(2-(18F)fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01)
    sub title: a multicentre, open-label, randomised trial
  title info:
    title: O-(2- (18 F)fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01)
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  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2026
    issuance: monographic
  abstract: Background - O-(2-[18F]fluoroethyl)-L-tyrosine (FET)-PET has a higher specificity than contrast-enhanced T1-weighted MRI (CE-T1MRI) in diagnosing recurrent glioblastoma. We aimed to evaluate whether a FET-PET-based target volume delineation, compared with CE-T1MRI, improves outcomes in patients with recurrent glioblastoma scheduled for re-irradiation. - Methods - GLIAA was a multicentre, open-label, parallel randomised study done in 15 radiation oncology centres in Germany. Patients aged 18 years or older with a Karnofsky performance score greater than 60% and a macroscopic WHO grade IV recurrent glioblastoma (1-6 cm) were randomly assigned (1:1) to receive either FET-PET-based or CE-T1MRI-based target volume delineation followed by re-irradiation with 39 Gy in 13 fractions. Randomisation was performed centrally, using a minimisation technique with a random element and a computer-assisted randomisation tool, stratified by time since first radiotherapy, previous chemotherapy, tumour diameter, MGMT status, and planned chemotherapy. The primary endpoint was progression-free survival from randomisation, assessed in the per-protocol population (patients who initiated treatment per their assigned group). Adverse events were systematically assessed in all patients who commenced therapy. The trial was registered with ClinicalTrials.gov (NCT01252459), German Clinical Trials Registry (DRKS00000634), and European Clinical Trials Database (EudraCT 2012-001121-27), and is completed. - Findings - Between Nov 22, 2013, and Aug 18, 2021, 271 patients were recruited and screened for eligibility, 200 of whom were randomly assigned to re-irradiation based on FET-PET (n=100) or CE-T1MRI (n=100). 85 (43%) participants were female and 115 (58%) were male. 98 patients in the FET-PET group and 97 in the CE-T1MRI group were treated per protocol. Median follow-up for censored patients was 12·2 months (IQR 6·6-20·7). Median progression-free survival was 4·0 months (95% CI 3·7-5·2) in the FET-…
  note: Anca-Ligia Grosu, Wolfgang A Weber, Erika Graf, Michael Mix, Ursula Nestle, Tanja Schimek-Jasch, Rolf Wiehle, Irina Mader, Urs Würtemberger, Karl-Josef Langen, Maximilian Niyazi, Frank Paulsen, Liane König, Frank Anton Giordano, Irina Spehl, Denise Bernhardt, Markus M Schymalla, Christoph Pöttgen, Sabine Semrau, Thomas Brunner, Beatrix Hültenschmidt, Bernd Joachim Krause, Ilja Frank Ciernik, Jürgen Beck, on behalf of the GLIAA Study Group
  note: Im Titel ist die Zahl 18 hochgestellt und "(18F)" in eckigen Klammern geschrieben
  note: Mitglieder der GLIAA Study Group: Brigitta G. Baumert, Philipp T. Meyer, Horst Urbach, Ilinca Popp, Claus Belka, Franziska Eckert, Michael J. Eble, Elena Sperk, Felix Momm, Stephanie E. Combs, Benedikt Wiestler, Rita Engenhart-Cabillic, Martin Stuschke, Rainer Fietkau, Stephan Nadji, Guido Hildebrandt, Arnab Chakravarti, Susan C. Short, Carsten Nieder, Sabine Schneider-Fuchs, Marco Prinz
  note: Online verfügbar: 19. Dezember 2025, Artikelversion: 2. Februar 2026
  note: Gesehen am 03.03.2026
  classification: 33
  identifier: https://doi.org/10.1016/S1470-2045(25)00642-4
  identifier: https://www.sciencedirect.com/science/article/pii/S1470204525006424

language term: eng

form: remote
extent: Illustrationen, Diagramme
extent: 12

title info:
  title: The lancet. Oncology
name:
  name part: O-(2-(18F)fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01) a multicentre, open-label, randomised trial
origin info:
  publisher: London : The Lancet Publ. Group, 2000
physical description:
  extent: Online-Ressource
identifier: 1474-5488
identifier: (DE-627)325349770
identifier: (DE-600)2035574-9
identifier: (DE-576)100517544
part:
  text: 27(2026), 2 vom: Feb., Seite 169-180

name:
  name part: O-(2-(18F)fluoroethyl)-L-tyrosine-PET-guided versus contrast-enhanced T1-weighted MRI-guided re-irradiation in patients with recurrent glioblastoma (GLIAA/NOA-10 ARO2013-01) a multicentre, open-label, randomised trial
part:
  text: volume:27
part:
  text: year:2026
part:
  text: number:2
part:
  text: month:02
part:
  text: pages:169-180
part:
  text: extent:12

record content source: DE-627
record creation date: 260303
record change date: 20260708134409.0
record identifier: 196329601X
language of cataloging:
  language term: ger