Safety and efficacy of tiragolumab, atezolizumab and chemotherapy for early-stage or PD-L1-positive advanced triple-negative breast cancer: a phase Ib study

Background - Immune checkpoint inhibitors have transformed the management of triple-negative breast cancer (TNBC) but outcomes could be improved further. We explored combining the T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) inhibitor tiragolumab with atezolizumab-containing re...

Full description

Saved in:

Bibliographic Details
Main Authors:	Kümmel, Sherko (Author) , Jung, K. H. (Author) , Andrade, L. (Author) , Assad-Suzuki, D. (Author) , de la Cruz Merino, L. (Author) , Freitas-Junior, R. (Author) , Hegg, R. (Author) , Huang, C. -S. (Author) , Martin, H. (Author) , Schneeweiss, Andreas (Author) , Dieterich, M. (Author) , Nguyen-Duc, Anh (Author) , Feng, Y. (Author) , Meng, R. (Author) , Swat, A. (Author) , Seiller, A. (Author) , Bermejo, B. (Author) , Hamilton, E. P. (Author)
Format:	Article (Journal)
Language:	English
Published:	December 2025
In:	ESMO open Year: 2025, Volume: 10, Issue: 12, Pages: 1-11
ISSN:	2059-7029
DOI:	10.1016/j.esmoop.2025.105869
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.esmoop.2025.105869 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2059702925017387
Author Notes:	S. Kuemmel, K.H. Jung, L. Andrade, D. Assad-Suzuki, L. de la Cruz Merino, R. Freitas-Junior, R. Hegg, C.-S. Huang, H. Martin, A. Schneeweiss, M. Dieterich, A. Nguyen Duc, Y. Feng, R. Meng, A. Swat, A. Seiller, B. Bermejo & E.P. Hamilton

Detection and isolation of circulating tumor cells from breast cancer patients using CUB domain-containing protein 1 by Bartkowiak, Kai (Author) , Mossahebi Mohammadi, Parinaz (Author) , Gärtner, Sebastian (Author) , Kwiatkowski, Marcel (Author) , Andreas, Antje (Author) , Geffken, Maria (Author) , Peine, Sven (Author) , Verpoort, Karl (Author) , Scholz, Ursula (Author) , Deutsch, Thomas M. (Author) , Michel, Laura L. (Author) , Schneeweiss, Andreas (Author) , Thewes, Verena (Author) , Trumpp, Andreas (Author) , Müller, Volkmar (Author) , Riethdorf, Sabine (Author) , Schlüter, Hartmut (Author) , Pantel, Klaus (Author) ,

in: Journal of proteome research, 22 (2023), 4 vom: März, Seite 1213-1230

Verlag, lizenzpflichtig, Volltext

Article (Journal) Online Resource

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer - lack of association between activating AKT mutation and AKT inhibition-derived... by Schneeweiss, Andreas (Author)

in: Cancers, 11 (2019,12) Artikel-Nummer 1987, 16 Seiten

Article (Journal) Online Resource

Safety and efficacy of tiragolumab, atezolizumab and chemotherapy for early-stage or PD-L1-positive advanced triple-negative breast cancer: a phase Ib study

Phase 1 dose escalation study of the allosteric AKT inhibitor BAY 1125976 in advanced solid cancer - lack of association between activating AKT mutation and AKT inhibition-derived... by Schneeweiss, Andreas (Author)

Similar Items