Prospective associations of blood-based biomarkers of neurodegenerative diseases with cognitive performance in a cohort of patients with chronic coronary syndrome
In a cohort of persons with chronic coronary syndrome, we investigated associations of blood-based biomarkers of neurodegenerative diseases with cognitive scores and mild cognitive impairment (MCI) after ten years. Biomarker levels were measured in baseline samples of serum (glial fibrillary acid pr...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
Dec 2025
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| In: |
Journal of Alzheimer's disease
Year: 2025, Volume: 108, Issue: 4, Pages: 1507-1513 |
| ISSN: | 1875-8908 |
| DOI: | 10.1177/13872877251389147 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/13872877251389147
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| Author Notes: | Valerie Lohner, Laura Perna, Ben Schottker, Robert Perneczky, Matthias Kliegel, Hermann Brenner and Ute Mons |
| Summary: | In a cohort of persons with chronic coronary syndrome, we investigated associations of blood-based biomarkers of neurodegenerative diseases with cognitive scores and mild cognitive impairment (MCI) after ten years. Biomarker levels were measured in baseline samples of serum (glial fibrillary acid protein, neurofilament light chain (NfL), phosphorylated tau181; n = 363) or plasma (amyloid-beta(42/40)-ratio, total-tau; n = 232). Cognitive scores and MCI were measured at ten-year follow-up using the Cognitive Telephone Screening Instrument. At follow-up, 14.7% had MCI. The amyloid-beta(42/40)-ratio was predictive of cognitive scores, while NfL was associated with increased risk of MCI, suggesting that these biomarkers might be utilized for risk stratification. |
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| Item Description: | Zuerst online veröffentlicht: November 18, 2025 Gesehen am 09.03.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1875-8908 |
| DOI: | 10.1177/13872877251389147 |