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Guidelines for next-generation sequencing in sarcoma diagnosis and treatment: a consensus review

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Sarcomas comprise a heterogeneous group of malignant neoplasms that include genomically simple (driven by recurrent genetic alterations) and genomically complex (characterized by extensive genomic rearrangements) subtypes. Regardless, sarcomas exhibit a remarkably low mutational burden. In this cont...

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Main Authors: Serrano, César (Author) , Bauer, Sebastian (Author) , Blay, Jean-Yves (Author) , Casali, Paolo G. (Author) , Cicala, Carlo M. (Author) , Dei Tos, Angelo P. (Author) , Digklia, Antonia (Author) , Gelderblom, Hans (Author) , Italiano, Antoine (Author) , Jones, Robin L. (Author) , Kasper, Bernd (Author) , Kyriazoglou, Anastasios (Author) , Le Loarer, Francois (Author) , Martin-Broto, Javier (Author) , Napolitano, Andrea (Author) , Rutkowski, Piotr (Author) , Stacchiotti, Silvia (Author) , Tap, William D. (Author) , Thomas, David (Author) , Thway, Khin (Author) , Valverde, Claudia (Author) , van der Graaf, Winette T. A. (Author) , Wardelmann, Eva (Author) , Bovée, Judith V. M. G. (Author)
Format: Article (Journal) Review
Language:English
Published: October 16, 2025
In: JAMA oncology
Year: 2025, Volume: 11, Issue: 12, Pages: 1527-1537
ISSN:2374-2445
DOI:10.1001/jamaoncol.2025.3608
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1001/jamaoncol.2025.3608
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Author Notes:César Serrano, Sebastian Bauer, Jean-Yves Blay, Paolo G. Casali, Carlo M. Cicala, Angelo P. Dei Tos, Antonia Digklia, Hans Gelderblom, Antoine Italiano, Robin L. Jones, Bernd Kasper, Anastasios Kyriazoglou, Francois Le Loarer, Javier Martín-Broto, Andrea Napolitano, Piotr Rutkowski, Silvia Stacchiotti, William Tap, David Thomas, Khin Thway, Claudia Valverde, Winette T. A. van der Graaf, Eva Wardelmann, Judith V. M. G. Bovée
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Guidelines for next-generation sequencing in sarcoma diagnosis and treatment: a consensus review by Serrano, César (Author) , Bauer, Sebastian (Author) , Blay, Jean-Yves (Author) , Casali, Paolo G. (Author) , Cicala, Carlo M. (Author) , Dei Tos, Angelo P. (Author) , Digklia, Antonia (Author) , Gelderblom, Hans (Author) , Italiano, Antoine (Author) , Jones, Robin L. (Author) , Kasper, Bernd (Author) , Kyriazoglou, Anastasios (Author) , Le Loarer, Francois (Author) , Martín-Broto, Javier (Author) , Napolitano, Andrea (Author) , Rutkowski, Piotr (Author) , Stacchiotti, Silvia (Author) , Tap, William (Author) , Thomas, David (Author) , Thway, Khin (Author) , Valverde, Claudia (Author) , van der Graaf, Winette T. A. (Author) , Wardelmann, Eva (Author) , Bovée, Judith V. M. G. (Author) ,


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