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Chronic Graft-versus-Host disease trends over 30 years: a study by the EBMT transplant complications working party

We assessed whether the incidence and outcomes of chronic Graft-versus-Host Disease (cGvHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) have changed over 30 years. We studied 102,275 adults with hematological malignancies receiving a first alloHSCT from identical siblings or...

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Main Authors: Pulanic, Drazen (Author) , Peczynski, Christophe (Author) , Boreland, William (Author) , Rautenberg, Christina (Author) , Kröger, Nicolaus (Author) , Michonneau, David (Author) , Salmenniemi, Urpu (Author) , Zeiser, Robert (Author) , Heidrich, Katharina (Author) , Forcade, Edouard (Author) , Blaise, Didier (Author) , Luft, Thomas (Author) , Labussière-Wallet, Hélène (Author) , Moiseev, Ivan (Author) , Könecke, Christian (Author) , Schoemans, Helene (Author) , Basak, Grzegorz W. (Author) , Penack, Olaf (Author) , Peric, Zinaida (Author)
Format: Article (Journal)
Language:English
Published: 19 August 2025
In: Bone marrow transplantation
Year: 2025, Volume: 60, Issue: 11, Pages: 1436-1444
ISSN:1476-5365
DOI:10.1038/s41409-025-02697-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/s41409-025-02697-w
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/s41409-025-02697-w
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Author Notes:Drazen Pulanic, Christophe Peczynski, William Boreland, Christina Rautenberg, Nicolaus Kröger, David Michonneau, Urpu Salmenniemi, Robert Zeiser, Katharina Egger-Heidrich, Edouard Forcade, Didier Blaise, Thomas Luft, Hélène Labussière-Wallet, Ivan Moiseev, Christian Koenecke, Helene Schoemans, Grzegorz Basak, Olaf Penack and Zinaida Peric
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Summary:We assessed whether the incidence and outcomes of chronic Graft-versus-Host Disease (cGvHD) after allogeneic hematopoietic stem cell transplantation (alloHSCT) have changed over 30 years. We studied 102,275 adults with hematological malignancies receiving a first alloHSCT from identical siblings or unrelated donors. We compared 3 decades: (I) 1990-1999 vs. (II) 2000-2009 vs. (III) 2010-2019. Over time, patients were older at transplantation, received more PBSC, unrelated donor transplants, reduced intensity conditioning, in vivo T-cell depletion and an ATG prophylaxis, and less TBI. cGvHD incidence at 48 months was 37.3% [36.2-38.4] in I decade vs. 44.9% [44.3-45.5] in II decade vs. 39.1% [38.7-39.5] in III decade, and incidence of extensive cGvHD at 48 months was 18.1% [17.3-19] vs. 22.2% [21.7-22.6] vs. 19.2% [18.9-19.5] over decades. In multivariate analysis, more cGvHD developed in II than in I decade (HR 1.14, 95% CI 1.09-1.21), but no difference was found between III and I decade (HR 1.01, 95% CI 0.96-1.06). Among patients with cGvHD, NRM at 48 months decreased over decades (21.3% [19.8-22.8] vs. 21% [20.3-21.7] vs. 19.7% [19.1-20.2], p < 0.001). Our data show unchanged cGvHD incidences over time and a high NRM in patients after cGvHD diagnosis.
Item Description:Online veröffentlicht: 19. August 2025
Gesehen am 11.03.2026
Physical Description:Online Resource
ISSN:1476-5365
DOI:10.1038/s41409-025-02697-w

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