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Dramatic response to entrectinib in a rare glioneuronal tumor harboring an NTRK2 fusion

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Glioneuronal tumors are rare CNS neoplasms that can exhibit overlapping histological features with embryonal tumors, posing diagnostic and therapeutic challenges. We report a case of a 19-year-old Tunisian woman with a large right frontal tumor and contralateral extension. Initial partial resection...

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Main Authors: Akrout, Firas (Author) , Bogumil, Henri (Author) , Yedeas, Mohamed Dehmani (Author) , Sievers, Philipp (Author) , Touat, Mehdi (Author) , Achoura, Sameh (Author)
Format: Article (Journal)
Language:English
Published: January 2026
In: The oncologist
Year: 2026, Volume: 31, Issue: 1, Pages: 1-6
ISSN:1549-490X
DOI:10.1093/oncolo/oyaf418
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1093/oncolo/oyaf418
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Author Notes:Firas Akrout, Henri Bogumil, Mohamed Dehmani Yedeas, Philipp Sievers, Mehdi Touat, Sameh Achoura
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CNS neuroblastoma, FOXR2-activated and its mimics: a relevant panel approach for work-up and accurate diagnosis of this rare neoplasm by Tauziède-Espariat, Arnault (Author) , Figarella-Branger, Dominique (Author) , Métais, Alice (Author) , Uro-Coste, Emmanuelle (Author) , Maurage, Claude-Alain (Author) , Lhermitte, Benoît (Author) , Aline-Fardin, Aude (Author) , Hasty, Lauren (Author) , Vasiljevic, Alexandre (Author) , Chiforeanu, Dan (Author) , Chotard, Guillaume (Author) , Adle-Biassette, Homa (Author) , Meurgey, Alexandra (Author) , Saffroy, Raphaël (Author) , Guillemot, Delphine (Author) , Pierron, Gaëlle (Author) , Sievers, Philipp (Author) , Varlet, Pascale (Author) ,


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Molecular analysis of pediatric CNS-PNET revealed nosologic heterogeneity and potent diagnostic markers for CNS neuroblastoma with FOXR2-activation by Korshunov, Andrey (Author) , Okonechnikov, Konstantin (Author) , Schmitt-Hoffner, Felix (Author) , Ryzhova, Marina (Author) , Sahm, Felix (Author) , Stichel, Damian (Author) , Schrimpf, Daniel (Author) , Reuss, David (Author) , Sievers, Philipp (Author) , Suwala, Abigail Kora (Author) , Jones, David T. W. (Author) , Pfister, Stefan (Author) , Kool, Marcel (Author) , Deimling, Andreas von (Author) ,


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