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Efficacy and safety of radiotherapy in head and neck paragangliomas: a retrospective 23-year analysis

Background/Objectives: Head and neck paragangliomas (HNPGs) are rare, typically benign, hypervascular tumors arising from neural crest cells. Although surgery is known as the primary treatment, radiotherapy (RT) is preferred for large and inoperable tumors. This study evaluated the results and safet...

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Main Authors: Cepni, Kimia (Author) , Dagdelen, Meltem (Author) , Oner, Huseyin (Author) , Cepni, Bahar (Author) , Kiziltan, Huriye Senay (Author) , Uzel, Omer Erol (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2026
In: Journal of Clinical Medicine
Year: 2026, Volume: 15, Issue: 3, Pages: 1-11
ISSN:2077-0383
DOI:10.3390/jcm15031062
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm15031062
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/15/3/1062
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Author Notes:Kimia Cepni, Meltem Dagdelen, Huseyin Oner, Bahar Cepni, Huriye Senay Kiziltan and Omer Erol Uzel
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Summary:Background/Objectives: Head and neck paragangliomas (HNPGs) are rare, typically benign, hypervascular tumors arising from neural crest cells. Although surgery is known as the primary treatment, radiotherapy (RT) is preferred for large and inoperable tumors. This study evaluated the results and safety of RT. Methods: Fifteen patients with radiologically or histologically confirmed HNPG treated with RT between 2001 and 2024 were retrospectively analyzed. Most patients received intensity-modulated radiotherapy (IMRT) with a median dose of 45 Gy. Treatment-related toxicities were graded according to CTCAE criteria. Local control (LC) was estimated with using Wilson score method. Results: With a median follow-up of 96 months, all patients achieved stable or improved symptomes, without local recurrence, resulting in a 100% LC rate. RT was well tolerated, with no acute or late toxicities ≥ grade 2. Conclusions: RT, particularly IMRT, provides excellent long-term LC with minimal toxicity in patients with HNPG. RT represents an effective and well-tolerated treatment option, especially for patients with unresectable disease or high surgical risk.
Item Description:Veröffentlicht: 29. Januar 2026
Gesehen am 20.03.2026
Physical Description:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm15031062

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