Feasibility study of using fast low-dose pencil beam proton and helium radiographs for intrafractional motion management
Purpose - This study aims to evaluate the feasibility of using fast, low-dose proton (pRad) and helium (HeRad) radiography for intrafractional motion management. This approach uses pencil ion beam delivery systems, modern particle imaging detectors and fast image reconstruction. - Methods - A plasti...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
1. Apri 2025
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| In: |
Physica medica
Year: 2025, Volume: 133, Pages: 1-10 |
| ISSN: | 1724-191X |
| DOI: | 10.1016/j.ejmp.2025.104959 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.ejmp.2025.104959 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1120179725000699 
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| Author Notes: | Alexander A. Pryanichnikov, Jennifer J. Hardt, Ethan A. DeJongh, Lukas Martin, Don F. DeJongh, Oliver Jäkel, Niklas Wahl, Joao Seco |
| Summary: | Purpose - This study aims to evaluate the feasibility of using fast, low-dose proton (pRad) and helium (HeRad) radiography for intrafractional motion management. This approach uses pencil ion beam delivery systems, modern particle imaging detectors and fast image reconstruction. - Methods - A plastic respiratory phantom underwent four-dimensional computed tomography (4DCT) using a commercial X-ray scanner, experimental pRad with a continuous proton beam from a clinical serial cyclotron, and experimental pRad and HeRad with pulsed proton and helium beams from a synchrotron-based ion therapy facility. Open-source patient 4DCT data were used in a Monte Carlo simulation study to evaluate pRad and HeRad in a realistic patient geometry. Treatment plans involving mixed carbon-helium beams were calculated using matRad and simulated in TOPAS. - Results - The experimental pRad achieved a temporal resolution of 8 fps for the cyclotron-based facility, while both pRad and HeRad achieved 2 fps for the synchrotron-based facility within a 10 cm × 10 cm region of interest. pRad reconstructed the respiratory phantom motion pattern with a dose of less than 2 µGy per image. In simulations of mixed carbon-helium beams, HeRad, both integral and single iso-energy, detected water equivalent thickness differences with sub-millimeter accuracy across different phases of the patient’s 4DCT data. - Conclusion - This study demonstrates that low-dose small-field proton and helium radiography, utilizing pencil beam scanning, can effectively monitor intrafractional anatomical displacements with millimeter-level spatial accuracy and sub-second temporal resolution. Current particle imaging and beam delivery technologies have the potential to enable real-time patient monitoring in promising mixed ion beam therapy. |
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| Item Description: | Online verfügbar: 1. April 2025 Gesehen am 23.03.2026 |
| Physical Description: | Online Resource |
| ISSN: | 1724-191X |
| DOI: | 10.1016/j.ejmp.2025.104959 |