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Seasonal community-acquired respiratory virus infections in patients with cancer: epidemiological and clinical overview, an analysis of the multicenter OncoReVir registry

Introduction - Community-acquired respiratory viruses (CARV) can cause severe infections in patients with cancer. To characterize epidemiology and outcome, the multicenter registry OncoReVir was established in November 2018. - Patients and Methods - From November 2018 to October 2024, 2080 patients...

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Autores principales: Rüthrich, Maria Madeleine (Autor) , Schmitt, Timo Martin (Autor) , Claßen, Annika (Autor) , Brandt, Juliane (Autor) , Spiekermann, Karsten (Autor) , Doleschal, Anna D. (Autor) , Seltmann, Alva (Autor) , Henze, Larissa (Autor) , Panse, Jens Peter (Autor) , Sauer, Gabriel (Autor) , Schmaedel, Katharina (Autor) , Schalk, Enrico (Autor) , Vehreschild, Maria J. G. T. (Autor) , Vehreschild, Jörg Janne (Autor) , Teschner, Daniel (Autor) , Lilienfeld-Toal, Marie von (Autor) , Giesen, Nicola (Autor)
Formato: Article (Journal)
Lenguaje:inglés
Publicado: April 2026
In: International journal of infectious diseases
Year: 2026, Volumen: 165, Pages: 1-8
ISSN:1878-3511
DOI:10.1016/j.ijid.2026.108421
Acceso en línea:Resolving-System, kostenfrei: https://dx.doi.org/10.1016/j.ijid.2026.108421
Resolving-System, kostenfrei, Volltext: https://doi.org/10.1016/j.ijid.2026.108421
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1201971226000561
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Notas de Autor:Maria M. Rüthrich, Timo Schmitt, Annika Y. Classen, Juliane Brandt, Karsten Spiekermann, Anna D. Doleschal, Alva Seltmann, Larissa Henze, Jens Panse, Gabriel Sauer, Katharina Schmaedel, Enrico Schalk, Maria J. G. T. Vehreschild, Jörg J. Vehreschild, Daniel Teschner, Marie von Lilienfeld-Toal, Nicola Giesen
Descripción
Sumario:Introduction - Community-acquired respiratory viruses (CARV) can cause severe infections in patients with cancer. To characterize epidemiology and outcome, the multicenter registry OncoReVir was established in November 2018. - Patients and Methods - From November 2018 to October 2024, 2080 patients with cancer and CARV infection were enrolled. Only patients with a single CARV infection were analyzed (n = 1975). Data included demographics, cancer characteristics, and clinical course. A subgroup (n = 381) compared epidemiology and outcome across pre-, peri-, and postpandemic periods. Predefined endpoints were pneumonia, ICU admission, and infection-related mortality. - Results - Median age was 61 years (interquartile range 52-69), 42.5% were female, and 85.5% had hematological diseases. Most frequent CARVs were severe acute respiratory coronavirus 2 (SARS-CoV-2) (36%), influenza (22.5%), human parainfluenza virus (hPIV, 12.5%), and respiratory syncytial virus (RSV, 12%). Epidemiology (excluding SARS-CoV-2) shifted by period: prepandemic, influenza predominated (70.5%); pandemic, RSV (31%); postpandemic, RSV (27.5%), and hPIV (25.5%). Overall, 53% patients were hospitalized, 7% required ICU care, pneumonia occurred in 22.5%, and infection-related mortality was 4% (overall mortality 28%). Endpoint occurrence varied minimally across phases. Influenza drove prepandemic severity, whereas other CARVs became relevant during/after the pandemic. - Conclusion - CARV epidemiology in patients with cancer changed substantially across pandemic phases, while clinical severity and infection-related mortality remained largely unchanged.
Notas:Online veröffentlicht am: 29. Januar 2026
Version of record: 12. März 2026
Gesehen am 09.09.2026
Descripción Física:Online Resource
ISSN:1878-3511
DOI:10.1016/j.ijid.2026.108421

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