rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Understanding the role of regulatory T cell-derived small extracellular vesicles in suppression of anti-tumor immune response
    sub title: key to advancing cancer immunotherapy
  name:
    name part: Seth, Pranav
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Pore, Subrata Kumar
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Ludwig, Sonja
    name part: 1987-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Sharma, Priyanka
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2026
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 23
  abstract: Regulatory T cells (Tregs) represent a distinct T cell subpopulation crucial for preserving immune homeostasis. Their primary function is to facilitate self-tolerance and suppress other immune responses, achieved through multifaceted mechanisms, including the secretion of extracellular vesicles (EVs) such as exosomes, which effectively modulate the activity of other innate and adaptive immune cells. Treg-derived extracellular vesicles (Treg-EVs) are minute, membrane-bound vesicles containing specific biological molecules, comprising proteins, nucleic acids, and lipids. Upon transfer to target cells, these molecules exert diverse effects on immune responses. The Treg-mediated immune suppression process encompasses several contact-dependent and contact-independent mechanisms. These encompass the expression of various inhibitory receptors, such as CTLA-4, PD-1, CD39, and CD73, which serve to regulate the immune response. Furthermore, Tregs exhibit the capacity to directly eliminate target cells through the expression of perforin and granzyme B. Additionally, Tregs produce immunosuppressive cytokines that play a pivotal role in maintaining immune system equilibrium. Studying the impact of Treg-derived exosomes on the immune system in cancer is crucial for advancing cancer research and treatment. Understanding these interactions is vital for unraveling the potential implications for cancer development and progression. Regulatory T cells, commonly called Tregs, represent a subset of white blood cells that play a pivotal role in modulating the immune system. Often termed suppressor T cells, Tregs are implicated in various immune system disorders when their function is compromised. Extracellular vesicles (EVs) released from these cells are minute particles, containing molecular components that mirror those of their originating cells and fulfill comparable physiological functions. Recent research has increasingly focused on small EVs derived from Tregs, which are instrumenta…
  note: Pranav Seth, Subrata Kumar Pore, Sonja Ludwig & Priyanka Sharma
  note: Gesehen am 07.04.2026
  subject:
    topic: Cancer progression
  subject:
    topic: cytokines
  subject:
    topic: exosomes
  subject:
    topic: immune suppression
  subject:
    topic: membrane-bound vesicles
  subject:
    topic: regulatory T cells
  classification: 33
  related item:
    title info:
      title: International reviews of immunology
    name:
      name part: Understanding the role of regulatory T cell-derived small extracellular vesicles in suppression of anti-tumor immune response key to advancing cancer immunotherapy
    origin info:
      publisher: Abingdon : Taylor & Francis Group, 1986
    physical description:
      extent: Online-Ressource
    identifier: 1563-5244
    identifier: (DE-627)324744412
    identifier: (DE-600)2030424-9
    identifier: (DE-576)273879855
    part:
      text: 45(2026), 3, Seite 161-183
  related item:
    name:
      name part: Understanding the role of regulatory T cell-derived small extracellular vesicles in suppression of anti-tumor immune response key to advancing cancer immunotherapy
    part:
      text: volume:45
    part:
      text: year:2026
    part:
      text: number:3
    part:
      text: pages:161-183
    part:
      text: extent:23
  identifier: https://doi.org/10.1080/08830185.2026.2631464
  record info:
    record content source: DE-627
    record creation date: 260407
    record change date: 20260511114905.0
    record identifier: 1967976996
    language of cataloging:
      language term: ger