Cover Image

Integrating SMRT and bulk RNA sequencing with metabolic phenotyping to examine reduced skeletal muscle mitochondrial respiration in type 2 Diabetes

Show other versions (2)

In our study, we developed a pipeline to integrate single-molecule real-time sequencing (SMRT-seq) with comprehensive metabolic phenotyping to examine reduced mitochondrial respiration in the skeletal muscle of individuals with type 2 diabetes.SMRT-seq revealed ∼67,000 isoforms originating from ∼14,...

Full description

Saved in:
Bibliographic Details
Main Authors: Schön, Martin (Author) , Oehler, Daniel (Author) , Yurchenko, Iryna (Author) , Lang, Alexander (Author) , Trinks, Nina (Author) , Dewidar, Bedair (Author) , Mastrototaro, Lucia (Author) , Zaharia, Oana P. (Author) , Bódis, Kálmán B. (Author) , Karusheva, Yanislava (Author) , Toledo, Frederico G.S. (Author) , Burkart, Volker (Author) , Granata, Cesare (Author) , Westenfeld, Ralf (Author) , Polzin, Amin (Author) , Kelm, Malte (Author) , Wagner, Robert (Author) , Roden, Michael (Author) , Szendrödi, Julia (Author)
Format: Article (Journal)
Language:English
Published: March 2026
In: Diabetes
Year: 2026, Volume: 75, Issue: 3, Pages: 571-581
ISSN:1939-327X
DOI:10.2337/db25-0625
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.2337/db25-0625
Get full text
Author Notes:Martin Schön, Daniel Oehler, Iryna Yurchenko, Alexander Lang, Nina Trinks, Bedair Dewidar, Lucia Mastrototaro, Oana P. Zaharia, Kálmán B. Bódis, Yanislava Karusheva, Frederico G.S. Toledo, Volker Burkart, Cesare Granata, Ralf Westenfeld, Amin Polzin, Malte Kelm, Robert Wagner, Michael Roden, and Julia Szendroedi, for the German Diabetes Study Group
Search Result 1
Cover Image

The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining by Mastrototaro, Lucia (Author) , Apostolopoulou, Maria (Author) , Hartwig, Sonja (Author) , Strassburger, Klaus (Author) , Lipaeva, Polina (Author) , Trinks, Nina (Author) , Karusheva, Yanislava (Author) , Gancheva, Sofiya (Author) , Trenkamp, Sandra (Author) , Lehr, Stefan (Author) , Al-Hasani, Hadi (Author) , Szendrödi, Julia (Author) , Roden, Michael (Author) ,


Get full text
Article (Journal) Online Resource

Saved in:
Search Result 2
Cover Image

Impaired hepatic mitochondrial capacity in nonalcoholic steatohepatitis associated with Type 2 diabetes by Gancheva, Sofiya (Author) , Kahl, Sabine (Author) , Pesta, Dominik (Author) , Mastrototaro, Lucia (Author) , Dewidar, Bedair (Author) , Strassburger, Klaus (Author) , Sabah, Ehsan (Author) , Esposito, Irene (Author) , Weiß, Jürgen (Author) , Sarabhai, Theresia (Author) , Wolkersdorfer, Martin (Author) , Fleming, Thomas (Author) , Nawroth, Peter Paul (Author) , Zimmermann, Marcel (Author) , Reichert, Andreas S. (Author) , Schlensak, Matthias (Author) , Roden, Michael (Author) ,


Get full text
Article (Journal) Online Resource

Saved in:
Show all versions (3)

Similar Items