rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Rewiring faces
    sub title: advances and outcomes in facial nerve reconstruction after facial vascularized composite allotransplantation
  name:
    name part: Knoedler, Leonard
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Niederegger, Tobias
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Munzinger, Robert
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Joshi, Surbhi
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Schaschinger, Thomas
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Cetrulo, Curtis L.
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Festbaum, Christian
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Kehrer, Andreas
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Hundeshagen, Gabriel
    name part: 1986-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Heiland, Max
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Koerdt, Steffen
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Neckel, Norbert
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Voss, Jan O.
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Lellouch, Alexandre G.
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2026
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: Illustrationen
    extent: 35
  abstract: BackgroundFacial vascularized composite allotransplantation (FVCA) provides transformative restoration for patients with severe craniofacial defects, but successful outcomes depend heavily on facial nerve (FN) reconstruction and reinnervation. Unlike standard nerve repair, FN coaptation in FVCA must address donor-recipient mismatch and immunologic variability. This systematic review synthesizes clinical and preclinical evidence on FN reconstruction strategies in FVCA and their functional outcomes.MethodsThis review adhered to PRISMA 2020 guidelines and was registered with PROSPERO (ID: CRD420251029430). A comprehensive search of PubMed, EMBASE, Cochrane Library, Web of Science, and Google Scholar. Methodological quality was assessed using the Newcastle-Ottawa Scale (NOS) and SYRCLE tool for preclinical studies.ResultsOverall, n = 45 (11%) studies [n = 41 (91%) human, n = 4 (9%) preclinical] published between 2006 and 2025 were included. Human studies were predominantly case reports n = 18 (44%), case series n = 11 (27%), and cadaveric investigations n = 9 (22%). Across n = 139 (100%) documented nerve repair interventions (NRIs), direct coaptation was performed in n = 20 (14%), most commonly at the FN trunk or its buccal, zygomatic, marginal mandibular, and frontal branches n = 28 (20%). Nerve grafting was more frequent, in n = 62 (45%), typically using great auricular or thoracodorsal donor nerves; only n = 2 (1.4%) NRIs employed dual-level trunk and branch coaptation. Synkinesis was reported in n = 11 (7.9%) NRIs, and patient-reported outcomes, though inconsistently collected, indicated improvements in oral continence, speech, social integration, and psychosocial well-being. Secondary revisions occurred in n = 27 (19%) and infectious complications in n = 12 (8.6%) NRIs. Preclinical rodent and porcine models corroborated clinical evidence that combined motor and sensory nerve repair enhances functional recovery.ConclusionFN reconstruction in FVCA is feasible and oft…
  note: Leonard Knoedler, Tobias Niederegger, Robert Munzinger, Surbhi Joshi, Thomas Schaschinger, Curtis L. Cetrulo, Christian Festbaum, Andreas Kehrer, Gabriel Hundeshagen, Max Heiland, Steffen Koerdt, Norbert Neckel, Jan O. Voss and Alexandre G. Lellouch
  note: Veröffentlicht: 30. Januar 2026
  note: Gesehen am 13.04.2026
  subject:
    topic: face transplantation
  subject:
    topic: facial nerve reconstruction
  subject:
    topic: functional facial reanimation
  subject:
    topic: nerve coaptation
  subject:
    topic: vascularized composite allotransplantation
  classification: 33
  related item:
    title info:
      title: Frontiers in Surgery
    name:
      name part: Rewiring faces advances and outcomes in facial nerve reconstruction after facial vascularized composite allotransplantation
    origin info:
      publisher: Lausanne : Frontiers Media, 2014
    physical description:
      extent: Online-Ressource
    identifier: 2296-875X
    identifier: (DE-627)788288954
    identifier: (DE-600)2773823-1
    identifier: (DE-576)408066717
    part:
      text: 13(2026), Artikel-ID 1738957, Seite 1-35
  related item:
    name:
      name part: Rewiring faces advances and outcomes in facial nerve reconstruction after facial vascularized composite allotransplantation
    part:
      text: volume:13
    part:
      text: year:2026
    part:
      text: elocationid:1738957
    part:
      text: pages:1-35
    part:
      text: extent:35
  identifier: https://doi.org/10.3389/fsurg.2026.1738957
  identifier: https://www.frontiersin.org/journals/surgery/articles/10.3389/fsurg.2026.1738957/full
  record info:
    record content source: DE-627
    record creation date: 260413
    record change date: 20260413123433.0
    record identifier: 1968412808
    language of cataloging:
      language term: ger