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Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD

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Altered respiratory barrier integrity and impaired lung regeneration are hallmarks of chronic obstructive pulmonary disease (COPD). To investigate the molecular mechanisms driving the impaired regeneration of alveolar epithelial progenitors in COPD, we generated whole-genome DNA methylation and tran...

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Main Authors: Llamazares Prada, Maria (Author) , Schwartz, Uwe (Author) , Pease, Darius F. (Author) , Pohl, Stephanie T. (Author) , Ackesson, Deborah (Author) , Li, Renjiao (Author) , Behrendt, Annika (Author) , Tamas, Raluca (Author) , Stammler, Vedrana (Author) , Richter, Mandy (Author) , Muley, Thomas (Author) , Scherer, Michael (Author) , Hey, Joschka (Author) , Espinet, Elisa (Author) , Heußel, Claus Peter (Author) , Warth, Arne (Author) , Schneider, Marc (Author) , Winter, Hauke (Author) , Herth, Felix (Author) , Imbusch, Charles (Author) , Brors, Benedikt (Author) , Benes, Vladimir (Author) , Wyatt, David (Author) , Jurkowski, Tomasz P. (Author) , Stahl, Heiko F. (Author) , Plass, Christoph (Author) , Jurkowska, Renata Z. (Author)
Format: Article (Journal)
Language:English
Published: 23 February 2026
In: EMBO molecular medicine
Year: 2026, Pages: 1-33
ISSN:1757-4684
DOI:10.1038/s44321-026-00386-9
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s44321-026-00386-9
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Author Notes:Maria Llamazares-Prada, Uwe Schwartz, Darius F Pease, Stephanie T Pohl, Deborah Ackesson, Renjiao Li, Annika Behrendt, Raluca Tamas, Vedrana Stammler, Mandy Richter, Thomas Muley, Michael Scherer, Joschka Hey, Elisa Espinet, Claus P Heußel, Arne Warth, Marc A Schneider, Hauke Winter, Felix JF Herth, Charles D Imbusch, Benedikt Brors, Vladimir Benes, David Wyatt, Tomasz P Jurkowski, Heiko F Stahl, Christoph Plass & Renata Z Jurkowska
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Hox-C9 activates the intrinsic pathway of apoptosis and is associated with spontaneous regression in neuroblastoma by Kocak, Hayriye (Author) , Ackermann, S. (Author) , Hero, B. (Author) , Kahlert, Y. (Author) , Oberthuer, A. (Author) , Juraeva, Dilafruz (Author) , Roels, F. (Author) , Theissen, J. (Author) , Westermann, Frank (Author) , Deubzer, Hedwig (Author) , Ehemann, Volker (Author) , Brors, Benedikt (Author) , Odenthal, M. (Author) , Berthold, F. (Author) , Fischer, M. (Author) ,


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