Epigenetic dysregulation of IRF9 drives excessive interferon signaling in COPD
Altered respiratory barrier integrity and impaired lung regeneration are hallmarks of chronic obstructive pulmonary disease (COPD). To investigate the molecular mechanisms driving the impaired regeneration of alveolar epithelial progenitors in COPD, we generated whole-genome DNA methylation and tran...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 February 2026
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| In: |
EMBO molecular medicine
Year: 2026, Pages: 1-33 |
| ISSN: | 1757-4684 |
| DOI: | 10.1038/s44321-026-00386-9 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s44321-026-00386-9
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| Verfasserangaben: | Maria Llamazares-Prada, Uwe Schwartz, Darius F Pease, Stephanie T Pohl, Deborah Ackesson, Renjiao Li, Annika Behrendt, Raluca Tamas, Vedrana Stammler, Mandy Richter, Thomas Muley, Michael Scherer, Joschka Hey, Elisa Espinet, Claus P Heußel, Arne Warth, Marc A Schneider, Hauke Winter, Felix JF Herth, Charles D Imbusch, Benedikt Brors, Vladimir Benes, David Wyatt, Tomasz P Jurkowski, Heiko F Stahl, Christoph Plass & Renata Z Jurkowska |