rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: bladder cancer m6A landscape is defined by global methylation dilution and focal 3′-UTR hypermethylation
  title info:
    title: The bladder cancer N6-Methyladenosine landscape is defined by global methylation dilution and focal three prime untranslated region hypermethylation
  title info:
    title: The bladder cancer m 6 A landscape is defined by global methylation dilution and focal 3′-UTR hypermethylation
  name:
    name part: Koch, Jonas
    name part: 1995-
    role:
      role term: creator
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Xu, Jinyun
    name part: 1995-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Bormann, Felix
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Coutinho Carneiro, Vitor
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Neuberger, Manuel
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Nitschke, Katja
    name part: 1984-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Nientiedt, Malin
    name part: 1991-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Erben, Philipp
    name part: 1973-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Michel, Maurice Stephan
    name part: 1970-
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Rodríguez Paredes, Manuel
    role:
      role term: VerfasserIn
    role:
      role term: aut
  name:
    name part: Lyko, Frank
    role:
      role term: VerfasserIn
    role:
      role term: aut
  type of resource: text
  origin info:
    place:
      place term: xx
    date issued: 2026
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: Diagramme
    extent: 26
  abstract: N6-Methyladenosine (m6A) is the most abundant internal modification of eukaryotic mRNAs and regulates target transcripts throughout the mRNA life cycle. Although changes in m6A have been reported in human cancers, technical limitations have hindered a comprehensive understanding of the cancer-associated m6A landscape. Here, we use GLORI-sequencing to establish the first transcriptome-wide, single-nucleotide resolution maps of m6A in bladder cancer. Comparing bladder cancer and healthy bladder samples, we discover two key m6A signatures: a global dilution of methylation and a focal hypermethylation at 3′-UTRs. The global methylation dilution results from an increased expression of unmethylated transcripts and a decreased expression of methylated transcripts. In contrast, focal 3’-UTR hypermethylation is associated with the overexpression of VIRMA, a component of the m6A writer complex. A functional role of VIRMA is confirmed in knockdown experiments that reveal reduced 3’-UTR methylation and oncogenic phenotypes of bladder cancer cells. Our study is the first to describe the m6A epitranscriptomic landscape of cancer at single-base resolution and provides first insights into the processes that generate its characteristic signatures.
  note: Jonas Koch, Jinyun Xu, Felix Bormann, Vitor Coutinho Carneiro, Manuel Neuberger, Katja Nitschke, Malin Nientiedt, Philipp Erben, Maurice Stephan Michel, Manuel Rodriguez-Paredes & Frank Lyko
  note: Im Titel ist die Zahl 6 hochgestellt
  note: Gesehen am 14.04.2026
  subject:
    topic: Cancer
  subject:
    topic: Epitranscriptomics
  subject:
    topic: GLORI
  subject:
    topic: m6A
  subject:
    topic: VIRMA
  classification: 33
  related item:
    title info:
      title: EMBO reports
    name:
      name part: European Molecular Biology Organization
    origin info:
      publisher: [London] : Nature Publishing Group UK, 2000
    physical description:
      extent: Online-Ressource
    identifier: 1469-3178
    identifier: (DE-627)320645622
    identifier: (DE-600)2025376-X
    identifier: (DE-576)095092153
    part:
      text: 27(2026), 8, Seite 2118-2143
  related item:
    name:
      name part: The bladder cancer m6A landscape is defined by global methylation dilution and focal 3′-UTR hypermethylation
    part:
      text: volume:27
    part:
      text: year:2026
    part:
      text: number:8
    part:
      text: pages:2118-2143
    part:
      text: extent:26
  identifier: https://doi.org/10.1038/s44319-026-00739-y
  record info:
    record content source: DE-627
    record creation date: 260414
    record change date: 20260706122350.0
    record identifier: 1968482113
    language of cataloging:
      language term: ger