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The role of zongertinib, a highly selective tyrosine kinase inhibitor, in targeting HER2-mutant NSCLC: a bench-to-bedside review

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HER2 is mutated in 2-4% of non-small cell lung cancers (NSCLC) and is associated with poor prognosis. Tyrosine kinase inhibitors (TKIs) targeting HER2 have historically been hampered by insufficient efficacy against exon 20 insertion mutations and lack of specificity, resulting in off-target adverse...

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Main Authors: Heymach, John (Author) , Popat, Sanjay (Author) , Smit, Egbert F. (Author) , Christopoulos, Petros (Author) , Planchard, David (Author) , Yoshida, Tatsuya (Author) , Zugazagoitia, Jon (Author) , Yu, Yan (Author) , Wilding, Birgit (Author)
Format: Article (Journal)
Language:English
Published: 18 Feb 2026
In: Expert review of anticancer therapy
Year: 2026, Pages: 1-11
ISSN:1744-8328
DOI:10.1080/14737140.2026.2623059
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1080/14737140.2026.2623059
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Author Notes:John V. Heymach, Sanjay Popat, Egbert F. Smit, Petros Christopoulos, David Planchard, Tatsuya Yoshida, Jon Zugazagoitia, Yan Yu and Birgit Wilding
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Real-world characteristics, treatment patterns, and outcomes in advanced HER2 (ERBB2)-mutant non-small cell lung cancer: a retrospective study of single centers in France and Germa... by Christopoulos, Petros (Author) , Assmann, Christin (Author) , Zhang, Lirong (Author) , Dunton, Kyle (Author) , Ali, Ahmed (Author) , Berktas, Mehmet (Author) , Delmastro, Lisa (Author) , Strübing, Alessandria (Author) , Xiong, Yan (Author) , Lay-Flurrie, Sarah (Author) , Hindocha, Pooja (Author) , Mehdikhanova, Tarana (Author) , Girard, Nicolas (Author) ,


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Specific targeting of antiapoptotic Bcl-2 proteins as a radiosensitizing approach in solid tumors by Sobol, Benjamin (Author) , Azzam Nieto, Osama (Author) , Eberlein, Emily Lara (Author) , Scherr, Anna-Lena (Author) , Ismail, Lars (Author) , Keßler, Annika (Author) , Nader, Luisa (Author) , Schwab, Maximilian (Author) , Hoffmeister-Wittmann, Paula (Author) , Schmitt, Nathalie (Author) , Jäger, Dirk (Author) , Welte, Stefan Ezechiel (Author) , Seidensaal, Katharina (Author) , Christopoulos, Petros (Author) , Heilig, Christoph E. (Author) , Kriegsmann, Katharina (Author) , Fröhling, Stefan (Author) , Kriegsmann, Mark (Author) , Heß, Jochen (Author) , Köhler, Bruno Christian (Author) ,


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Efficacy of immune checkpoint inhibitors alone or in combination with chemotherapy in NSCLC harboring ERBB2 mutations by Saalfeld, Felix (Author) , Wenzel, Carina (Author) , Christopoulos, Petros (Author) , Merkelbach-Bruse, Sabine (Author) , Reissig, Timm M. (Author) , Laßmann, Silke (Author) , Thiel, Sebastian (Author) , Stratmann, Jan A. (Author) , Marienfeld, Ralf (Author) , Berger, Johannes (Author) , Desuki, Alexander (Author) , Velthaus, Janna-Lisa (Author) , Kauffmann-Guerrero, Diego (Author) , Stenzinger, Albrecht (Author) , Michels, Sebastian (Author) , Herold, Thomas (Author) , Kramer, Michael (Author) , Herold, Sylvia (Author) , Tufman, Amanda (Author) , Loges, Sonja (Author) , Alt, Jürgen (Author) , Joosten, Maria (Author) , Schmidtke-Schrezenmeier, Gerlinde (Author) , Sebastian, Martin (Author) , Stephan-Falkenau, Susann (Author) , Waller, Cornelius F. (Author) , Wiesweg, Marcel (Author) , Wolf, Jürgen (Author) , Thomas, Michael (Author) , Aust, Daniela E. (Author) , Wermke, Martin (Author) ,


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