Genomic characterization of colorectal tumors: insights into significantly mutated genes, pathways, and survival outcomes

Identifying significantly mutated genes in tumors aids in understanding disease etiology and survival and may aid in the discovery of new drug targets. We aimed to detect and characterize mutated genes from a large, well-characterized group of colorectal cancers.

Bibliographic Details

Main Authors:	Harrison, Tabitha A. (Author) , Zaidi, Syed H. (Author) , Yin, Hang (Author) , Steinfelder, Robert S. (Author) , Qu, Conghui (Author) , Aglago, Elom K. (Author) , Berndt, Sonja I. (Author) , Boardman, Lisa A. (Author) , Brenner, Hermann (Author) , Buchanan, Daniel D. (Author) , Campbell, Peter T. (Author) , Cao, Yin (Author) , Chan, Andrew T. (Author) , Chanock, Stephen J. (Author) , Doheny, Kimberly F. (Author) , Drew, David A. (Author) , Figueiredo, Jane C. (Author) , French, Amy J. (Author) , Gallinger, Steven (Author) , Georgeson, Peter (Author) , Giannakis, Marios (Author) , Goode, Ellen L. (Author) , Gruber, Stephen B. (Author) , Gsur, Andrea (Author) , Gunter, Marc J. (Author) , Harlid, Sophia (Author) , Hoffmeister, Michael (Author) , Huang, Wen-Yi (Author) , Hullar, Meredith AJ. (Author) , Huyghe, Jeroen R. (Author) , Jenkins, Mark A. (Author) , Lin, Yi (Author) , Moreno, Victor (Author) , Murphy, Neil (Author) , Newcomb, Polly A. (Author) , Newton, Christina C. (Author) , Nowak, Jonathan A. (Author) , Obón-Santacana, Mireia (Author) , Ogino, Shuji (Author) , Shelford, Tameka (Author) , Song, Mingyang (Author) , Thomas, Claire E. (Author) , Toland, Amanda E. (Author) , Ugai, Tomotaka (Author) , Um, Caroline Y. (Author) , Van Guelpen, Bethany (Author) , Trinh, Quang M. (Author) , Sun, Wei (Author) , Hudson, Thomas J. (Author) , Hsu, Li (Author) , Peters, Ulrike (Author) , Phipps, Amanda I. (Author)
Format:	Article (Journal)
Language:	English
Published:	18 December 2025
In:	BMC cancer Year: 2025, Volume: 26, Pages: 1-14
ISSN:	1471-2407
DOI:	10.1186/s12885-025-15440-x
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-025-15440-x
Author Notes:	Tabitha A. Harrison, Syed H. Zaidi, Hang Yin, Robert S. Steinfelder, Conghui Qu, Elom K. Aglago, Sonja I. Berndt, Lisa A. Boardman, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Yin Cao, Andrew T. Chan, Stephen J. Chanock, Kimberly F. Doheny, David A. Drew, Jane C. Figueiredo, Amy J. French, Steven Gallinger, Peter Georgeson, Marios Giannakis, Ellen L. Goode, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Sophia Harlid, Michael Hoffmeister, Wen-Yi Huang, Meredith AJ. Hullar, Jeroen R. Huyghe, Mark A. Jenkins, Yi Lin, Victor Moreno, Neil Murphy, Polly A. Newcomb, Christina C. Newton, Jonathan A. Nowak, Mireia Obón-Santacana, Shuji Ogino, Tameka Shelford, Mingyang Song, Claire E. Thomas, Amanda E. Toland, Tomotaka Ugai, Caroline Y. Um, Bethany Van Guelpen, Quang M. Trinh, Wei Sun, Thomas J. Hudson, Li Hsu, Ulrike Peters and Amanda I. Phipps