Diagnostic whole transcriptome sequencing in a series of 1233 FFPE solid tumor samples

Whole Transcriptome Sequencing (WTS) is a comprehensive alternative to targeted panels for detecting gene fusions and splice variants. To integrate WTS into clinical diagnostics, we compared its performance against established fusion assays (Archer FusionPlex and TSO500 RNA).

Bibliographic Details

Main Authors:	Ball, Markus (Author) , Beck, Susanne (Author) , Wlochowitz, Darius (Author) , Fuchs, Tina (Author) , Lorenz, Katja (Author) , Zgorzelski, Christiane (Author) , Pallares Robles, Alejandro (Author) , Allgäuer, Michael (Author) , Volckmar, Anna-Lena (Author) , Goldschmid, Hannah (Author) , Ourailidis, Iordanis (Author) , Brandt, Regine (Author) , Christopoulos, Petros (Author) , Thomas, Michael (Author) , Şeker-Cin, Huriye (Author) , Fink, Annette (Author) , Schnecko, Fabian (Author) , Neumann, Olaf (Author) , Menzel, Michael (Author) , Kirchner, Martina (Author) , Fioretos, Thoas (Author) , Schirmacher, Peter (Author) , Peters, Solange (Author) , Budczies, Jan (Author) , Stenzinger, Albrecht (Author) , Kazdal, Daniel (Author)
Format:	Article (Journal)
Language:	English
Published:	05 April 2026
In:	British journal of cancer Year: 2026, Volume: 134, Issue: 7, Pages: 1101-1110
ISSN:	1532-1827
DOI:	10.1038/s41416-025-03307-8
Online Access:	Resolving-System, kostenfrei, Volltext: https://doi.org/10.1038/s41416-025-03307-8 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-025-03307-8
Author Notes:	Markus Ball, Susanne Beck, Darius Wlochowitz, Tina Fuchs, Katja Lorenz, Christiane Zgorzelski, Alejandro Pallares Robles, Michael Allgäuer, Anna-Lena Volckmar, Hannah Goldschmid, Iordanis Ourailidis, Regine Brandt, Petros Christopoulos, Michael Thomas, Huriye Seker-Cin, Annette Fink, Fabian Schnecko, Olaf Neumann, Michael Menzel, Martina Kirchner, Thoas Fioretos, Peter Schirmacher, Solange Peters, Jan Budczies, Albrecht Stenzinger and Daniel Kazdal