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The evolution of gene regulation in mammalian cerebellum development

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Gene regulatory changes are considered major drivers of evolutionary innovations, including the cerebellum’s expansion during human evolution, yet they remain largely unexplored. In this study, we combined single-nucleus measurements of gene expression and chromatin accessibility from six mammals (h...

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Main Authors: Sarropoulos, Ioannis (Author) , Sepp, Mari (Author) , Yamada, Tetsuya (Author) , Schäfer, Philipp (Author) , Trost, Nils (Author) , Schmidt, Julia (Author) , Schneider, Céline (Author) , Drummer, Charis (Author) , Mißbach, Sophie (Author) , Taskiran, Ibrahim I. (Author) , Hecker, Nikolai (Author) , Bravo González-Blas, Carmen (Author) , Frömel, Robert (Author) , Joshi, Piyush (Author) , Leushkin, Evgeny (Author) , Arnskötter, Carl Frederik (Author) , Leiss, Kevin (Author) , Okonechnikov, Konstantin (Author) , Lisgo, Steven (Author) , Palkovits, Miklós (Author) , Pääbo, Svante (Author) , Cardoso-Moreira, Margarida (Author) , Kutscher, Lena (Author) , Behr, Rüdiger (Author) , Pfister, Stefan (Author) , Aerts, Stein (Author) , Kaessmann, Henrik (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2026
In: Science
Year: 2026, Volume: 391, Issue: 6784, Pages: 1-25
ISSN:1095-9203
DOI:10.1126/science.adw9154
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.adw9154
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.adw9154
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Author Notes:Ioannis Sarropoulos, Mari Sepp, Tetsuya Yamada, Philipp S. L. Schäfer, Nils Trost, Julia Schmidt, Céline Schneider, Charis Drummer, Sophie Mißbach, Ibrahim I. Taskiran, Nikolai Hecker, Carmen Bravo González-Blas, Robert Frömel, Piyush Joshi, Evgeny Leushkin, Frederik Arnskötter, Kevin Leiss, Konstantin Okonechnikov, Steven Lisgo, Miklós Palkovits, Svante Pääbo, Margarida Cardoso-Moreira, Lena M. Kutscher, Rüdiger Behr, Stefan M. Pfister, Stein Aerts, Henrik Kaessmann
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The evolution of gene regulation in mammalian cerebellum development by Sarropoulos, Ioannis (Author) , Sepp, Mari (Author) , Yamada, Tetsuya (Author) , Schäfer, Philipp (Author) , Trost, Nils (Author) , Schmidt, Julia (Author) , Schneider, Céline (Author) , Drummer, Charis (Author) , Mißbach, Sophie (Author) , Taskiran, Ibrahim I. (Author) , Hecker, Nikolai (Author) , González-Blas, Carmen Bravo (Author) , Kempynck, Niklas (Author) , Frömel, Robert (Author) , Joshi, Piyush (Author) , Leushkin, Evgeny (Author) , Arnskötter, Carl Frederik (Author) , Leiss, Kevin (Author) , Okonechnikov, Konstantin (Author) , Lisgo, Steven (Author) , Palkovits, Miklós (Author) , Pääbo, Svante (Author) , Cardoso-Moreira, Margarida (Author) , Kutscher, Lena (Author) , Behr, Rüdiger (Author) , Pfister, Stefan (Author) , Aerts, Stein (Author) , Kaessmann, Henrik (Author) ,


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