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FDG-PET/CT based small volume accelerated immuno chemoradiotherapy in locally advanced NSCLC (PACCELIO): a randomized, open-label, multicenter phase II trial protocol : study protocol

Standard treatment for unresectable stage III non-small cell lung cancer (NSCLC) involves chemoradiation (CRT) followed by PD-L1 targeting immune checkpoint inhibition (IO). Integrating 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT into radiotherapy planning reduces toxicity, imp...

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Autori principali: El-Shafie, Rami (Autore) , Willmann, Jonas (Autore) , Gkika, Eleni (Autore) , Schimek-Jasch, Tanja (Autore) , Miederer, Matthias (Autore) , Bozorgmehr, Farastuk (Autore) , Griesinger, Frank (Autore) , Manapov, Farkhad (Autore) , Christopoulos, Petros (Autore) , Hehr, Thomas (Autore) , Hecht, Markus (Autore) , Bütof, Rebecca (Autore) , Stuschke, Martin (Autore) , Guckenberger, Matthias (Autore) , Schmid-Bindert, Gerald (Autore) , Meiners, Jan (Autore) , Herzer, Sascha (Autore) , Hartmann, Sonja (Autore) , Lamché, Joana (Autore) , Rieken, Stefan (Autore) , Nestle, Ursula (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: April 2026
In: BMC cancer
Year: 2026, Volume: 26, Pages: 1-15
ISSN:1471-2407
DOI:10.1186/s12885-026-15901-x
Accesso online:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12885-026-15901-x
Testo
Note sull'autore:Rami El Shafie, Jonas Willmann, Eleni Gkika, Tanja Schimek-Jasch, Matthias Miederer, Farastuk Bozorgmehr, Frank Griesinger, Farkhad Manapov, Petros Christopoulos, Thomas Hehr, Markus Hecht, Rebecca Bütof, Martin Stuschke, Matthias Guckenberger, Gerald Schmid-Bindert, Jan Meiners, Sascha Herzer, Sonja Hartmann, Joana Lamché, Stefan Rieken and Ursula Nestle
Descrizione
Riassunto:Standard treatment for unresectable stage III non-small cell lung cancer (NSCLC) involves chemoradiation (CRT) followed by PD-L1 targeting immune checkpoint inhibition (IO). Integrating 18 F-fluorodeoxyglucose-positron emission tomography (FDG-PET)/CT into radiotherapy planning reduces toxicity, improves CRT outcomes, and potentially enhances immunotherapy response. Hypofractionated, accelerated CRT shortens treatment time, improves compliance, and may increase CRT completion rates, qualifying more patients for consolidative IO.
Descrizione del documento:Online veröffentlicht: 17. April 2026
Gesehen am 21.05.2026
Descrizione fisica:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-026-15901-x

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