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EML4−ALK variant-specific genetic interactions shape lung tumorigenesis

EML4-ALK-driven lung cancer is treated as a uniform disease despite the presence of distinct fusion variants in patients. Our findings show that EML4-ALK variants are functionally distinct, which may have implications for the treatment of this cancer type and highlights the need to consider differen...

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Autori principali: Díaz-Jiménez, Alberto (Autore) , Shuldiner, Emily G. (Autore) , Somogyi, Kálmán (Autore) , Shih, Karen Y. (Autore) , González-Velasco, Óscar (Autore) , Najajreh, Mulham (Autore) , Kim, Stewart (Autore) , Akkas, Filiz (Autore) , Murray, Christopher W. (Autore) , Andrejka, Laura (Autore) , Tsai, Min K. (Autore) , Brors, Benedikt (Autore) , Hofmann, Ilse (Autore) , Sivakumar, Smruthy (Autore) , Sisoudiya, Saumya D. (Autore) , Sokol, Ethan S. (Autore) , Cai, Hongchen (Autore) , Petrov, Dmitri A. (Autore) , Winslow, Monte M. (Autore) , Sotillo, Rocio (Autore)
Natura: Article (Journal)
Lingua:inglese
Pubblicazione: January 2026
In: Cancer discovery
Year: 2026, Volume: 16, Fascicolo: 1, Pages: 46-65
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-24-1417
Accesso online:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1158/2159-8290.CD-24-1417
Verlag, lizenzpflichtig, Volltext: https://aacrjournals.org/cancerdiscovery/article/16/1/46/771237/EML4-ALK-Variant-Specific-Genetic-Interactions?guestAccessKey=
Testo
Note sull'autore:Alberto Diaz-Jimenez, Emily G. Shuldiner, Kalman Somogyi, Karen Y. Shih, Óscar González-Velasco, Mulham Najajreh, Stewart Kim, Filiz Akkas, Christopher W. Murray, Laura Andrejka, Min K. Tsai, Benedikt Brors, Ilse Hofmann, Smruthy Sivakumar, Saumya D. Sisoudiya, Ethan S. Sokol, Hongchen Cai, Dmitri A. Petrov, Monte M. Winslow, and Rocio Sotillo
Descrizione
Riassunto:EML4-ALK-driven lung cancer is treated as a uniform disease despite the presence of distinct fusion variants in patients. Our findings show that EML4-ALK variants are functionally distinct, which may have implications for the treatment of this cancer type and highlights the need to consider differences among variants of other oncogenic fusions.
Descrizione del documento:Gesehen am 22.05.2026
Descrizione fisica:Online Resource
ISSN:2159-8290
DOI:10.1158/2159-8290.CD-24-1417

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