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The impact of age on survival and excess mortality after autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients

Despite the availability of novel agents, autologous hematopoietic cell transplantation (auto-HCT) remains the standard of care in newly diagnosed multiple myeloma (MM) patients. The impact of age on overall survival (OS), progression-free survival (PFS), relapse incidence, non-relapse mortality (NR...

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Main Authors: Mizuno, Shohei (Author) , Gras, Luuk (Author) , Baaij, Laurien G. A. (Author) , Koster, Linda (Author) , D'Souza, Anita (Author) , Hari, Parameswaran N. (Author) , Estrada-Merly, Noel (Author) , Saber, Wael (Author) , Cowan, Andrew J. (Author) , Iida, Minako (Author) , Okamoto, Shinichiro (Author) , Takamatsu, Hiroyuki (Author) , Kawamura, Koji (Author) , Kodera, Yoshihisa (Author) , Hamad, Nada (Author) , Ko, Bor-Sheng (Author) , Liam, Christopher (Author) , Ho, Kim Wah (Author) , Goh, Ai Sim (Author) , Keat, Tan Sui (Author) , Elhaddad, Alaa M. (Author) , Bazarbachi, Ali (Author) , Chaudhry, Brig Qamar Un N. (Author) , Alfar, Rozan (Author) , Bekadja, Mohamed Amine (Author) , Benakli, Malek (Author) , Ortiz, Cristobal Augusto Frutos (Author) , Riva, Eloisa (Author) , Verburgh, Estelle (Author) , Galeano, Sebastian (Author) , Bass, Francisca (Author) , Mian, Hira (Author) , McCurdy, Arleigh (Author) , Wang, Feng Rong (Author) , Neumann, Daniel (Author) , Koh, Mickey Boon Chai (Author) , Snowden, John A. (Author) , Schönland, Stefan (Author) , McLornan, Donal P. (Author) , Hayden, Patrick J. (Author) , Balari, Anna Maria Sureda (Author) , Greinix, Hildegard T. (Author) , Aljurf, Mahmoud (Author) , Atsuta, Yoshiko (Author) , Rondelli, Damiano (Author) , Niederwieser, Dietger W. (Author) , Garderet, Laurent (Author)
Format: Article (Journal)
Language:English
Published: January, 2026
In: Haematologica
Year: 2026, Volume: 111, Issue: 1, Pages: 286-299
ISSN:1592-8721
DOI:10.3324/haematol.2025.288041
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.3324/haematol.2025.288041
Verlag, kostenfrei, Volltext: https://haematologica.org/article/view/12198
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Author Notes:Shohei Mizuno, Luuk Gras, Laurien G.A. Baaij, Linda Koster, Anita D'Souza, Parameswaran N. Hari, Noel Estrada-Merly, Wael Saber, Andrew J. Cowan, Minako Iida, Shinichiro Okamoto, Hiroyuki Takamatsu, Koji Kawamura, Yoshihisa Kodera, Nada Hamad, Bor-Sheng Ko, Christopher Liam, Kim Wah Ho, Ai Sim Goh, Tan Sui Keat, Alaa M. Elhaddad, Ali Bazarbachi, Brig Qamar Un N. Chaudhry, Rozan Alfar, Mohamed Amine Bekadja, Malek Benakli, Cristobal Augusto Frutos Ortiz, Eloisa Riva, Estelle Verburgh, Sebastian Galeano, Francisca Bass, Hira Mian, Arleigh McCurdy, Feng Rong Wang, Daniel Neumann, Mickey Boon Chai Koh, John A. Snowden, Stefan Schönland, Donal P. McLornan, Patrick J. Hayden, Anna Maria Sureda Balari, Hildegard T. Greinix, Mahmoud Aljurf, Yoshiko Atsuta, Damiano Rondelli, Dietger W. Niederwieser and Laurent Garderet for the Worldwide Network of Blood and Marrow Transplantation
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Summary:Despite the availability of novel agents, autologous hematopoietic cell transplantation (auto-HCT) remains the standard of care in newly diagnosed multiple myeloma (MM) patients. The impact of age on overall survival (OS), progression-free survival (PFS), relapse incidence, non-relapse mortality (NRM), and excess mortality (taking account of general population mortality) was investigated using information on 61,797 MM patients transplanted between 2013 and 2017. The median age at auto-HCT was 60.8 (range, 18.1-83.2) years of whom 2.0% were 18-39 years, 68.9% 40-64 years, 21.8% 65-69 years, 6.5% 70-74 years, and 0.8% ≥75 years of age, respectively. The corresponding OS probabilities at 3 years were 85.9%, 82.8%, 81.1%, 78.4%, and 74.8%, respectively (P<0.001). Excess mortality cumulative incidences were 13.1%, 15.0%, 14.6%, 15.0%, and 14.1% at 3 years, respectively (P=0.67). In multivariable analyses, older age was a significant risk factor for OS, PFS, and NRM but not for excess mortality or relapse risk. Our results indicate that advanced age alone should not preclude the use of auto- HCT in patients with MM.
Item Description:Online verfügbar: 31. Juli 2025
Gesehen am 22.05.2026
Physical Description:Online Resource
ISSN:1592-8721
DOI:10.3324/haematol.2025.288041

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