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Results of a multicenter, randomized trial examining a new transition model for post-kidney transplant adolescents

Allograft loss after pediatric kidney transplantation (KTx) is highest in adolescents and young adults. Non-adherence and Health Care Transition (HCT) are important factors, but others also contribute. In the TransNephro study patients were randomized 1:1. The intervention group was included in the...

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Hauptverfasser: Kreuzer, Martin (Verfasst von) , Prüfe, Jenny (Verfasst von) , Dierks, Marie-Luise (Verfasst von) , Müther, Silvia (Verfasst von) , Bethe, Dirk (Verfasst von) , Büscher, Anja (Verfasst von) , Heindl-Rusai, Krisztina (Verfasst von) , Hollenbach, Sabine (Verfasst von) , Hoppe, Bernd (Verfasst von) , John-Kroegel, Ulrike (Verfasst von) , Kanzelmeyer, Nele Kirsten (Verfasst von) , Klaus, Günter (Verfasst von) , Kranz, Birgitta (Verfasst von) , Oh, Jun (Verfasst von) , Pohl, Martin (Verfasst von) , Rieger, Susanne (Verfasst von) , Ruckenbrodt, Bettina (Verfasst von) , Sauerstein, Katja (Verfasst von) , Staude, Hagen (Verfasst von) , Taylan, Christina (Verfasst von) , Thumfart, Julia Angelika (Verfasst von) , Weitz, Marcus (Verfasst von) , Ringlstetter, Rieke (Verfasst von) , Großhennig, Anika (Verfasst von) , Pape, Lars (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 April 2025
In: Scientific reports
Year: 2025, Jahrgang: 15, Pages: 1-10
ISSN:2045-2322
DOI:10.1038/s41598-025-95845-7
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41598-025-95845-7
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41598-025-95845-7
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Verfasserangaben:Martin Kreuzer, Jenny Prüfe, Marie-Luise Dierks, Silvia Müther, Dirk Bethe, Anja Büscher, Krisztina Heindl-Rusai, Sabine Hollenbach, Bernd Hoppe, Ulrike John-Kroegel, Nele Kirsten Kanzelmeyer, Günter Klaus, Birgitta Kranz, Jun Oh, Martin Pohl, Susanne Rieger, Bettina Ruckenbrodt, Katja Sauerstein, Hagen Staude, Christina Taylan, Julia Thumfart, Marcus Weitz, Rieke Ringlstetter, Anika Großhennig & Lars Pape
Beschreibung
Zusammenfassung:Allograft loss after pediatric kidney transplantation (KTx) is highest in adolescents and young adults. Non-adherence and Health Care Transition (HCT) are important factors, but others also contribute. In the TransNephro study patients were randomized 1:1. The intervention group was included in the Berlin Transition Program (BTP) and incorporated a central case manager, a communication app, and joined transition rounds for one year before and one year after transfer. Primary endpoint was the coefficient of variation (CoV) of the trough level of the calcineurin inhibitor as a surrogate marker for medication adherence associated with graft loss. Least square (LS) mean differences and corresponding 95% confidence intervals (CIs) were estimated using an analysis of covariance (ANCOVA) model. We assessed 220 patients for eligibility. 49 patients were randomized to the intervention group and 53 to the control group. We analyzed 84 patients in the modified intention-to-treat analysis (38 intervention, 46 controls) and 60 in the per protocol analysis (25 intervention, 35 controls). We found no difference in CoV. We saw low numbers of graft-related events and observed no differences with respect to quality of life. BTP did not improve adherence and other outcome parameters. Non-adherent patients may have decided not to participate, whilst adherence of participants was already good at study start. It is therefore achallenge to design future multicenter trials on HCT that include multiple interventions.
Beschreibung:Veröffentlicht: 03. April 2025
Gesehen am 26.05.2026
Beschreibung:Online Resource
ISSN:2045-2322
DOI:10.1038/s41598-025-95845-7

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