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Mavacamten in symptomatic nonobstructive hypertrophic cardiomyopathy

In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten.

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Bibliographic Details
Main Authors: Desai, Milind (Author) , Owens, Anjali T. (Author) , Abraham, Theodore (Author) , Olivotto, Iacopo (Author) , García-Pavía, Pablo (Author) , Lopes, Renato D. (Author) , Elliott, Perry (Author) , Fernandes, Fabio (Author) , Verheyen, Nicolas (Author) , Maier, Lars (Author) , Meder, Benjamin (Author) , Azevedo, Olga (Author) , Kitaoka, Hiroaki (Author) , Wolski, Kathy (Author) , Wang, Qiuqing (Author) , Jaber, Wael (Author) , Mitchell, Lisa (Author) , Myers, Jonathan (Author) , Rano, Thomas (Author) , Gong, Zhiqun (Author) , Zhong, Yue (Author) , Carter-Bonanza, Suzanne (Author) , Florea, Victoria (Author) , Aronson, Ron (Author) , Nissen, Steven E. (Author)
Format: Article (Journal)
Language:English
Published: September 11, 2025
In: The New England journal of medicine
Year: 2025, Volume: 393, Issue: 10, Pages: 961-972
ISSN:1533-4406
DOI:10.1056/NEJMoa2505927
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2505927
Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2505927
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Author Notes:M.Y. Desai, A.T. Owens, T. Abraham, I. Olivotto, P. Garcia-Pavia, R.D. Lopes, P. Elliott, F. Fernandes, N. Verheyen, L. Maier, B. Meder, O. Azevedo, H. Kitaoka, K. Wolski, Q. Wang, W. Jaber, L. Mitchell, J. Myers, T. Rano, Z. Gong, Y. Zhong, S. Carter-Bonanza, V. Florea, R. Aronson, and S.E. Nissen
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Summary:In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten.
Item Description:Online veröffentlicht am: 30. August 2025
Gesehen am 27.05.2026
Physical Description:Online Resource
ISSN:1533-4406
DOI:10.1056/NEJMoa2505927

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